Actively Recruiting
Network Targeted Transcranial Direct Current Stimulation (tDCS) as a Treatment for Laryngeal Dystonia (LD)
Led by Yale University · Updated on 2026-02-09
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Spasmodic Dysphonia Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of transcranial direct current stimulation (tDCS) as a potential treatment for laryngeal dystonia, a voice disorder formerly known as spasmodic dysphonia. This study involves participants clinically diagnosed with various types of laryngeal dystonia including adductor, abductor, and mixed types. The study is sponsored by Yale University and aims to explore brain stimulation effects on this condition. Participants will undergo neuromodulation using a device called the Starstim system to deliver tDCS for twenty minutes while either watching videos or performing a word production task. Before treatment sessions, baseline brain activity will be recorded using MRI and EEG scans. Each participant will attend multiple testing sessions over a five-day period to receive the stimulation and complete assessments. During the study, researchers will measure changes in voice quality daily using tools such as Cepstral Peak Prominence (CPP) and the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V). Participants will be monitored throughout the five-day testing period to evaluate treatment effects. The total participation time spans these multiple sessions, with no mention of long-term follow-up beyond the study period.
CONDITIONS
Brief Title
tDCS for Laryngeal Dystonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be clinically evaluated for the diagnosis of LD or have proof of LD diagnosis (not applicable for control participants)
- No other known or history of speech or voice disorder other than LD
- Provide signed and dated informed consent
- Willingness to comply with all study procedures and availability for the study duration
- Must not be pregnant
You will not qualify if you...
- Not meeting the inclusion criteria
- History of epilepsy
- History of depression
- Claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 5 days
Participants receive transcranial direct current stimulation (tDCS) for twenty minutes daily while watching videos or performing a word production task.
Multiple testing sessions over a 5-day period
Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06511
Actively Recruiting
Research Team
N
Nabin Koirala, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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