Actively Recruiting

Phase Not Applicable
Age: 20Years - 80Years
All Genders
Healthy Volunteers
NCT07168031

tDCS of the Left dlPFC: Effects on Information Processing

Led by University of Bern · Updated on 2025-09-11

196

Participants Needed

1

Research Sites

103 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study investigates how a non-invasive form of brain stimulation, called transcranial direct current stimulation (tDCS), affects brain activity and information processing in younger and older adults. The stimulation uses a very weak electrical current applied through electrodes placed on the scalp. This method is safe and widely used in research to study brain function. Participants will complete computer-based tasks while receiving either active brain stimulation or a placebo (sham) stimulation. The task is designed to engage specific mental processes so that the investigators can study how the brain responds under different conditions. Brain activity will be measured using magnetic resonance imaging (MRI), both while participants perform the tasks and while they are resting. The study will compare healthy younger (ages 20-40) and older (ages 60-80) adults to explore whether age influences how the brain responds to stimulation. By examining patterns of brain activation and connectivity, the investigators aim to better understand how tDCS can modulate cognitive processing across the adult lifespan. The hypothesis is that applying tDCS to the left dorsolateral prefrontal cortex will change patterns of brain activity related to cognitive processing, and that these changes may differ between younger and older adults. This knowledge could help inform future research into brain stimulation techniques in different age groups.

CONDITIONS

Official Title

tDCS of the Left dlPFC: Effects on Information Processing

Who Can Participate

Age: 20Years - 80Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Healthy younger adults aged 20 to 40 years or healthy older adults aged 60 to 80 years
  • Normal or corrected-to-normal vision and hearing
  • Right-handed individuals
  • Able to provide written informed consent and comply with study procedures
Not Eligible

You will not qualify if you...

  • History of neurological or psychiatric disorders
  • Current use of medications affecting the central nervous system
  • Metal implants, pacemakers, or other contraindications for MRI or tDCS
  • History of seizures or epilepsy
  • Pregnancy
  • Participation in another brain stimulation study within the last 3 months
  • Any condition judged by investigators to interfere with safe participation

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

University of Bern, Department of Old Age Psychiatry and Psychotherapy

Bern, Switzerland, 3000

Actively Recruiting

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Research Team

S

Sarah Godehardt

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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