Actively Recruiting
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-05-13
2950
Participants Needed
1
Research Sites
438 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Researchers are testing version of a system known as a magnetic resonance imagining (MRI) scanner that uses strong magnetic fields, radio waves and the like to create images of the organs in the body. It uses lower energy levels than other MRI scanners. This may help scan people with metal devices in their body, or in invasive heart procedures using metal tools. Objective: To test a new MRI scanner and software changes to create better pictures. Eligibility: People with disease and healthy volunteers, ages 18 and older. Design: Participants will be screened with blood tests. Participants may have both the new MRI and a conventional MRI or only the new one. If 2 are done, they must be within 60 days. For both MRI versions, participants lie on a table that slides into a large tube. During scans, they will hold their breath for up to 20 seconds at a time. Heart activity will be measured by wires connected to pads on the skin. A flexible belt may be used to monitor their breathing. They will be in the scanner up to 2 hours. Participants can agree to have a dye called gadolinium injected into their arm during the scan. This brightens the pictures. Participants can agree to take a drug called a vasodilator. This helps detect areas of the heart with abnormal blood supply. Scans of the heart are taken before, during, and after they get the medicine. The drug may cause temporary chest pain or shortness of breath. They may get other drugs to relieve these symptoms. Sponsoring Institution: National Heart, Lung, and Blood Institute
CONDITIONS
Official Title
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women age 18 years or older
- Able to provide written informed consent
- Willing to cooperate with all study procedures and available for scheduled events
- Healthy volunteers currently self-reporting good health (objectives 1 and 2)
- Adults with known stable heart disease including angina, past heart attack, heart failure, valve disease, pulmonary hypertension, congenital heart disease, myocarditis, infiltrative or hypertrophic cardiomyopathy (objective 3)
- Adults with known non-cardiac diseases such as brain conditions, musculoskeletal disorders, abdominal or lung diseases (objective 4)
- Subjects using bronchodilators routinely or with previous pulmonary function testing who agree to bronchodilator testing during MRI
You will not qualify if you...
- Any condition making MRI unsafe, including certain metal implants, clips, stimulators, or foreign bodies not labeled safe for MRI
- Pregnancy (unless confirmed negative by testing within 3 days) or breastfeeding unless willing to discard milk for 24 hours if contrast used
- Kidney function below specified thresholds preventing gadolinium contrast use
- More than two research MRIs with gadolinium in past 12 months
- Allergy or refusal to gadolinium, ferumoxytol, or oral contrast agents
- Severe chronic obstructive pulmonary disease requiring multiple bronchodilators daily or continuous oxygen
- Prior bleomycin treatment
- Important past medical illness in healthy volunteers
- Unstable or recent heart conditions in cardiac patients
- Asthma or COPD severity excluding vasodilator stress MRI
- Advanced heart block on ECG
- Acute illness delaying care in non-cardiac patients
- Refusal of bronchodilator administration
- Specific restrictions for cardiac implanted electronic devices depending on MRI type and device age
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
A
Anastasia Tsakirellis, C.R.N.P.
CONTACT
A
Adrienne E Campbell, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
FACTORIAL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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