Actively Recruiting
Technical Development of Cardiovascular Magnetic Resonance Imaging
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-05-04
3400
Participants Needed
2
Research Sites
403 weeks
Total Duration
On this page
Sponsors
N
National Heart, Lung, and Blood Institute (NHLBI)
Lead Sponsor
M
Medstar Health Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Background: In the U.S., over 6.5 million people have heart failure. Researchers want to develop new testing methods for cardiovascular problems using magnetic resonance imaging (MRI) to improve the clinical diagnosis and management of people with heart failure. Objective: To develop and test new methods for imaging the heart and blood vessels using MRI. Eligibility: People ages 18 years and older who are having an MRI of their heart or blood vessels. Healthy volunteers are also needed. Design: Participants will be screened with a medical history. Participants will have a physical exam and blood tests. They will have an electrocardiogram (ECG) to measure the heart s electrical activity. Then they will have their scheduled MRI scan. The MRI scanner is a large, hollow tube. Participants will lie on a table that moves in and out of the tube. During the MRI, they may have contrast dye injected through an intravenous line inserted into their arm or hand. ECG may be used to monitor their heartbeat or coordinate pictures with their heartbeat. A flexible belt may be used to monitor their breathing. A finger probe may be used to track their heart rate and/or oxygenation level. Their blood pressure may be measured. Pictures may be taken of their blood vessels, heart, and lungs before, during, and after they get medicine to increase blood flow. They may lie flat and pedal a stress bicycle to increase their heart rate. Participation will last for 5 years. During that time, participants may receive a yearly survey about their health. They may be contacted for an optional follow-up MRI within 2 years of their MRI.
CONDITIONS
Official Title
Technical Development of Cardiovascular Magnetic Resonance Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and availability for the duration of the study
- Male or female, 18 years or older
- Undergoing a clinically indicated MRI for heart or blood vessel conditions such as heart failure, cardiomyopathy, chest pain, coronary artery disease, dyspnea, valve disease, congenital heart disease, cardiac masses, aortic disease, exposure to cardiotoxic drugs, or systemic illnesses affecting the heart
- Healthy volunteers aged 18 years or older willing to participate in developmental testing and reference value establishment
You will not qualify if you...
- Cannot undergo MRI due to implanted devices or metal objects unless cleared as safe for MRI
- For contrast-enhanced MRI with gadolinium: kidney dysfunction with low filtration rate or known allergy to gadolinium contrast
- For MRI with ferumoxytol contrast: known allergy to ferumoxytol or mannitol excipient
- Contraindications to pharmacological stress tests including bronchospastic lung disease with wheezing, certain heart conduction diseases without pacemaker, low systolic blood pressure (< 90 mmHg), uncontrolled hypertension, recent dipyridamole use, hypersensitivity to stress agents
- Unstable angina, recent acute coronary syndrome or recent heart attack (within 2-4 days)
- Seizure disorder for regadenoson use
- Pregnant or lactating women (unless willing to discard breast milk for 24 hours after gadolinium administration)
- Healthy volunteers with major illnesses including hypertension requiring medication, myocardial infarction, diabetes, familial hypercholesterolemia, cardiomyopathy, congenital heart disease, moderate or severe valve disease, cerebrovascular or peripheral vascular disease, symptoms of angina or dyspnea, current smokers
- Decisionally impaired individuals
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Medstar Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
2
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Stacian D Awojoodu, C.R.N.P.
CONTACT
E
Eric E Morgan, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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