Actively Recruiting
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-04-29
5000
Participants Needed
1
Research Sites
507 weeks
Total Duration
On this page
Sponsors
N
National Heart, Lung, and Blood Institute (NHLBI)
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs. Researchers want to find better MRI methods and new ways of imaging cardiovascular disease and better understand normal and abnormal cardiovascular and brain function. Researchers are also interested in seeing if gadolinium, the commonly used MRI contrast agent, stays in the body long after the MRI was performed. Objectives: To develop new methods for imaging the heart and other organs of the body. To describe cardiovascular diseases using newer MRI methods To look at the relationship between cardiovascular disease and cardiovascular risk factors and other organ systems To look for gadolinium deposits in the brain from prior exams. Eligibility: Healthy people and people with known or suspected cardiovascular disease ages 7 and older may be eligible for this study. Researchers may be particularly interested in those who: * Have suspected or known cardiovascular disease * Were previously exposed to a gadolinium-based contrast agent, * Need to have a heart MRI scheduled * Need a test of the heart or other body part or will be undergoing a future cardiac catheterization Design: There are multiple arms to the study with optional components; therefore, there are multiple variations as to what an individual participant s experience may involve. Participants will have an MRI scan lasting up to 2 hours. The scanner is a large hollow tube. During the scan, there may be loud knocking and buzzing sounds caused by the scanner. Participants will lie on a table that slides in and out of the tube. Their vital signs may be monitored. Participants may have a test of heart electrical activity using wires connected to pads on the skin. Participants may have blood drawn. Participants may be injected with an MRI contrast agent through a plastic tube inserted in the arm.
CONDITIONS
Official Title
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 7 years or older
- Able to follow instructions and lie still during MRI
- Able to provide informed consent or guardian consent
- Willing to cooperate with study procedures and attend scheduled events
- Healthy volunteers must be without known cardiovascular disease
- Subjects with known or suspected cardiovascular disease
- Subjects with known or suspected non-cardiac diseases such as brain, hematology, oncology, endocrine, or pulmonary conditions
You will not qualify if you...
- Major cardiovascular illness like myocardial infarction, congenital heart disease, or known cardiomyopathy (for healthy volunteers)
- Any condition or implanted device unsafe for MRI, such as non-MRI-safe pacemakers, defibrillators, aneurysm clips, neural stimulators, cochlear implants, ocular metal foreign bodies, or metal shrapnel/bullets not cleared by x-ray
- Estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73m² for healthy volunteers or below 30 mL/min/1.73m² for subjects with disease
- Pregnancy; subjects will have pregnancy testing if uncertain
- Breastfeeding unless willing to discard breast milk for 24 hours if receiving contrast
- Cardiorespiratory instability as determined by clinician (for subjects with disease)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
J
Jennifer L Henry, R.N.
CONTACT
W
W. Patricia Bandettini, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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