Actively Recruiting
Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
Led by Aaron Cook · Updated on 2025-12-26
20
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
Sponsors
A
Aaron Cook
Lead Sponsor
C
Cumberland Pharmaceuticals
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs). Patients with EVDs were chosen as the target population because they frequently require prolonged admission to the intensive care unit and drainage of CSF in order to prevent hydrocephalus. The estimated sample size is 20 subjects. This is a prospective cohort of patients with SAH. Patients will be included if they have an in-dwelling EVD, aged 18-85 years old. Subjects will receive telavancin 10mg/kg (maximum 1000mg) every 24 hours for 3 consecutive doses. Serial serum and CSF samples will be obtained. An 8-hour urine collection will be completed on study day 2 in order to define the patient's measured creatinine clearance.
CONDITIONS
Official Title
Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult aged 18-85 years
- Actively draining ventriculostomy
You will not qualify if you...
- History of hypersensitivity to telavancin or similar agents
- Reduced renal function (estimated creatinine clearance < 50 ml/min) at the time of consent
- Severe anemia (hemoglobin < 7 gm/dl)
- Vulnerable population (pregnant, prisoner)
- Concomitant antimicrobial therapy
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
Research Team
A
Aaron Cook, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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