Actively Recruiting
Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure
Led by Azienda Unita Sanitaria Locale di Piacenza · Updated on 2026-04-13
90
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, randomized, open-label, no-profit interventional trial designed to evaluate the effectiveness of a telemedicine-based follow-up strategy compared with standard ambulatory care in patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF). The study aims to determine whether telemedicine-guided management improves the optimization of guideline-directed medical therapy (GDMT), measured as change in GDMT score at 6 months. Patients will be randomized to either a telemedicine group, involving remote multiparametric monitoring and structured teleconsultations, or a standard-of-care group based on conventional in-person follow-up. Secondary objectives include the assessment of safety, treatment adherence, quality of life, and heart failure-related urgent visits, emergency department access, and hospitalizations. This study will provide evidence on the role of telemedicine in facilitating early and effective optimization of heart failure therapy and improving clinical management in a real-world setting.
CONDITIONS
Official Title
Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent provided
- Age 18 years or older
- Recent diagnosis of heart failure with reduced ejection fraction (HFrEF) according to ESC criteria
- No prior initiation of guideline-directed medical therapy (GDMT) for heart failure, or treatment limited to one agent prescribed for another condition
- Adequate digital literacy by patient or caregiver for remote communication and monitoring
- Any cause of heart failure, including ischemic, valvular, cardiomyopathies, iatrogenic, toxic, or tachycardia-induced
You will not qualify if you...
- Ongoing treatment with two or more guideline-directed heart failure medications at HFrEF diagnosis
- Severe comorbidities or clinical instability requiring prolonged hospital care
- Estimated life expectancy less than 12 months
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Clinical Research Office, AUSL Piacenza
Piacenza, Italy, Italy, 29121
Actively Recruiting
Research Team
C
Clinical Research Office, AUSL Piacenza
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here