Actively Recruiting
Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
Led by Shanghai University of Sport · Updated on 2026-01-06
36
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether a type of brain stimulation called transcranial temporal interference stimulation (TIS) of the internal globus pallidus (GPi) can help improve movement symptoms in people with Parkinson's disease. The study will also look at how TIS changes brain activity related to these improvements. The main questions this study aims to answer are: * How much can repeated TIS sessions improve movement symptoms in people with Parkinson's disease? * Can these improvements last for up to two months after the treatment ends? * What changes in brain activity happen along with the improvements? Researchers will compare people who receive active TIS with those who receive sham (placebo-like) stimulation to see whether active TIS leads to better movement outcomes. Participants will: * Receive 10 sessions of active or sham TIS over two weeks * Complete movement assessments during the two-week treatment and again 2, 4, and 8 weeks afterward * Complete brain activity assessments before and after the two-week treatment
CONDITIONS
Official Title
Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with idiopathic Parkinson's disease by a physician using MDS criteria, with disease onset after age 40
- Stable Parkinson's medication, including levodopa, unchanged for at least 4 weeks before and during the study
- Hoehn and Yahr stage between 1.5 and 3
- Able to walk without help
- Montreal Cognitive Assessment score of 21 or higher indicating no dementia
- Aged between 50 and 80 years
You will not qualify if you...
- Any contraindications for MRI or TIS, such as claustrophobia, metal implants in head or heart, or past electroconvulsive therapy
- Currently taking antipsychotic, antidepressant, or other dopamine-modulating drugs
- Orthopedic issues that affect movement tests, including osteoarthritis or recent surgery within 6 months
- History of major psychiatric illness diagnosed by a physician
- Cardiovascular risks that prevent exercise or study participation
- Previous deep brain stimulation surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai University of Sport
Shanghai, Shanghai Municipality, China, 200438
Actively Recruiting
Research Team
Y
Yu Liu, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here