Tesamorelin Treatment to Improve Recovery and Function After Peripheral Nerve Injury

What this Trial Is About

Researchers are studying the use of tesamorelin as a possible treatment to improve recovery after peripheral nerve injuries, specifically focusing on patients with ulnar nerve lacerations at the wrist that have been surgically repaired. The study aims to determine whether tesamorelin can speed up and enhance the return of motor and sensory functions after such injuries. This is a randomized, double-blinded clinical trial designed to evaluate the effects of tesamorelin compared to no treatment in this patient group. Participants will be randomly assigned to one of two groups one receiving daily self-administered tesamorelin at a dose of 2 milligrams, and the other receiving no drug treatment. There will be 36 participants in total, with 18 individuals in each group. The study will last for about four years, including 12 monthly follow-up visits after enrollment. During these visits, assessments will be conducted to measure nerve regeneration, muscle function, and sensation using clinical exams, electrodiagnostic studies, and questionnaires. Throughout the 12-month follow-up period, investigators will regularly evaluate recovery using tests such as the 3-point chuck pinch test and various questionnaires including the Disability of the Arm, Shoulder, and Hand DASH score and the Michigan Hand Questionnaire. Additional measurements will include response amplitude, latency, velocity, and sensory and motor grading scales. The study will monitor participant progress closely to compare outcomes between those receiving tesamorelin and those not receiving treatment, aiming to understand tesamorelins potential benefits in nerve injury recovery.

Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury