Actively Recruiting
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
Led by NHS Greater Glasgow and Clyde · Updated on 2025-01-14
20
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
Sponsors
N
NHS Greater Glasgow and Clyde
Lead Sponsor
G
Galapagos NV
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an experimental medicine, single-centre, observational test-retest study to evaluate Filgotinib's mechanism of analgesic action in RA patients. The investigators hypothesize that Filgotinib's mechanism of analgesic action is determined by at least two factors. The first is related to those CNS sensitization pathways seen in fibromyalgia, specifically DMN-insula brain functional connectivity and insular glutamate. The second is related to peripheral inflammation, specifically joint synovitis, blood cytokines/chemokines and DAN-LIPL functional brain connectivity. The CNS sensitization pain pathways related to fibromyalgia are more quickly modified compared to those related to peripheral inflammation and help explain Filgotinib's rapid onset of effect.
CONDITIONS
Official Title
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to less than 75 years with moderate to severe active rheumatoid arthritis
- Patients prescribed Filgotinib according to product guidelines
- Right-handed individuals to reduce brain imaging variability
You will not qualify if you...
- Unable to provide written informed consent
- Severe physical impairment such as blindness, deafness, or paraplegia
- Pregnant or breastfeeding women
- Severe claustrophobia preventing MRI
- Any contraindications to MRI
- Major neurological diseases like multiple sclerosis, stroke, or traumatic brain injury
- Previous use of targeted synthetic DMARDs (e.g., baricitinib, tofacitinib) for rheumatoid arthritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Neil Basu
Glasgow, United Kingdom
Actively Recruiting
Research Team
M
Maxine Arnott
CONTACT
N
Neil Basu, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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