Actively Recruiting
Testing Health Workers At Risk to Advance Our Understanding of TB Infection
Led by Beth Israel Deaconess Medical Center · Updated on 2025-05-23
300
Participants Needed
1
Research Sites
311 weeks
Total Duration
On this page
Sponsors
B
Beth Israel Deaconess Medical Center
Lead Sponsor
U
University of Stellenbosch
Collaborating Sponsor
AI-Summary
What this Trial Is About
It has been estimated that 1.7 billion people have tuberculosis (TB) infection; yet current tests are unable to predict which people are at highest risk of developing TB disease, which can be life-threatening. THWART-TB is a prospective longitudinal cohort study of health workers (HWs) in Cape Town, South Africa, where our preliminary data reveals HWs have a high annual TB infection risk (34%). This cohort, who will undergo frequent serial evaluation (every 3 months) with a combination of novel assays never previously evaluated together, presents a unique opportunity to evaluate immune responses at the time of initial infection and to characterize the dynamic profile of these immune responses over time in a high-risk population. The knowledge generated will improve our understanding of TB infection and help to identify which people exposed to TB may remain at risk, enabling us to better target preventive strategies.
CONDITIONS
Official Title
Testing Health Workers At Risk to Advance Our Understanding of TB Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- Health worker
- Able to provide informed consent
You will not qualify if you...
- Prior history of tuberculosis (TB) or known prior positive interferon gamma release assay (IGRA)
- Current or prior history of taking anti-TB treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Stellenbosch University
Cape Town, South Africa
Actively Recruiting
Research Team
R
Ruvandhi Nathavitharana, MBBS MPH
CONTACT
G
Grant Theron, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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