Actively Recruiting
Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease
Led by Weill Medical College of Cornell University · Updated on 2025-10-01
120
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
T
The Leona M. and Harry B. Helmsley Charitable Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about the effects of fluconazole in patients who plan to start or are currently undergoing standard of care treatment and plan to dose-escalate an IL-23 therapy for their Crohn's disease. The main question it aims to assess is whether or not patient response to IL-23 therapies improve when simultaneously treated with fluconazole.
CONDITIONS
Official Title
Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients at least 18 years old
- Patients with mild to moderate Crohn's disease as defined by CDAI score of 150-450
You will not qualify if you...
- Antifungal use within one month before starting fluconazole treatment
- Known allergy to fluconazole
- Known liver disease, cirrhosis, or elevated liver tests above specified limits
- Use of medications that interact with fluconazole causing serious side effects
- Pregnant or breastfeeding women
- Severe Crohn's disease or need for surgery as determined by physician
- Symptomatic stricturing
- Presence of pouchitis or ostomy
- Active fungal infections requiring special treatment
- Low potassium levels or advanced heart failure
- Kidney problems
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
Research Team
C
Caroline Ericsson, BS
CONTACT
A
Aurelia Li, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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