Actively Recruiting
Testing Use of Topical Imipramine in Reducing Ultraviolet B Induced Microvesicle Particle Release in Photosensitive Subjects
Led by Wright State University · Updated on 2025-01-27
40
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is three-fold. First, researchers will assess whether subjects who have clinically abnormal reactions to sunlight (photosensitivity) have increased levels of microvesicle particles (MVP) following ultraviolet B (UVB) treatment to localized area of skin. Second, researchers will assess if topical application of the medicine imipramine will block UVB-induced MVP release. Third, researchers will assess if the topical cream will block UVB-induced increased erythema reactions (reddening of the skin).
CONDITIONS
Official Title
Testing Use of Topical Imipramine in Reducing Ultraviolet B Induced Microvesicle Particle Release in Photosensitive Subjects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female and male adults aged 18 to 50
- Able to give informed consent
- Have stable transportation access
- All skin types on Fitzpatrick Scale (Type I-VI)
- Self-identified photosensitivity
- Able to provide medical history and list of medications; control subjects not taking photosensitizing medications
You will not qualify if you...
- Underlying diseases affecting wound healing (e.g., uncontrolled diabetes mellitus)
- Taking photosensitizing medications (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDs except low-dose aspirin, steroids)
- Using imipramine or other tricyclic antidepressants (oral or cream)
- Using topical anti-inflammatory or systemic agents (e.g., prednisone)
- Large tattoos in testing areas
- Tanning bed use within last 3 months
- Photodynamic therapy or UVB treatments in last 3 months
- Female subjects who are pregnant or nursing
- History of abnormal scarring such as keloids
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Wright State Physicians
Fairborn, Ohio, United States, 45324
Actively Recruiting
Research Team
M
Manager Clinical Research Operations
CONTACT
R
Regulatory Specialist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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