Actively Recruiting
Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
Led by SWOG Cancer Research Network · Updated on 2026-01-22
528
Participants Needed
174
Research Sites
487 weeks
Total Duration
On this page
Sponsors
S
SWOG Cancer Research Network
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase III trial compares the effect of adding carboplatin to the standard of care chemotherapy drug cabazitaxel versus cabazitaxel alone in treating prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low levels (castrate-resistant) and that has spread from where it first started (primary site) to other places in the body (metastatic). Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Chemotherapy drugs, such as cabazitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Prednisone is often given together with chemotherapy drugs. Prednisone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs and to help the chemotherapy work. Giving carboplatin with the standard of care chemotherapy drug cabazitaxel may be better at treating metastatic castrate-resistant prostate cancer.
CONDITIONS
Official Title
Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be male and 18 years or older.
- Participants must have a confirmed diagnosis of prostate cancer.
- Participants must have castrate-resistant prostate cancer with metastatic disease confirmed by imaging.
- Participants must have previously received docetaxel treatment.
- Participants must have tumor biopsy tissue available for molecular testing.
- Participants must provide informed consent.
- Participants must have castrate levels of testosterone (<50 ng/dL) before randomization.
- Participants must have evidence of disease progression based on imaging or rising PSA levels.
- Participants must have adequate blood counts and organ function within 28 days prior to randomization.
- Participants must have a Zubrod performance status of 0 to 2.
- Participants must agree to use effective contraception if of reproductive potential.
- Participants must not have received prior cabazitaxel or carboplatin treatments.
- Participants must not be currently enrolled in another therapeutic clinical trial.
- Participants must not have untreated fractures or symptomatic uncontrolled brain metastases.
- Participants must have a complete medical history and physical exam within 28 days prior to randomization.
- Participants must be willing to provide specimens for banking.
You will not qualify if you...
- Participants who have received prior cabazitaxel or carboplatin chemotherapy.
- Participants currently receiving treatment on another therapeutic clinical trial.
- Participants who have received radiation therapy or major surgery within specified timeframes before randomization.
- Participants with untreated fractures or symptomatic uncontrolled brain metastases.
- Participants with severe peripheral neuropathy (greater than grade 2).
- Participants with a prior or concurrent malignancy that may interfere with treatment assessment.
- Participants without adequate blood counts or organ function.
- Participants not meeting castrate testosterone levels.
- Participants with uncontrolled infections or other medical conditions that could interfere with the study.
- Participants who cannot provide informed consent or do not agree to specimen banking.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 174 locations
1
Highlands Oncology Group - Fayetteville
Fayetteville, Arkansas, United States, 72703
Actively Recruiting
2
Highlands Oncology Group - Rogers
Rogers, Arkansas, United States, 72758
Actively Recruiting
3
Highlands Oncology Group
Springdale, Arkansas, United States, 72762
Actively Recruiting
4
Tibor Rubin VA Medical Center
Long Beach, California, United States, 90822
Actively Recruiting
5
Beebe Medical Center
Lewes, Delaware, United States, 19958
Actively Recruiting
6
Beebe South Coastal Health Campus
Millville, Delaware, United States, 19967
Actively Recruiting
7
Helen F Graham Cancer Center
Newark, Delaware, United States, 19713
Actively Recruiting
8
Medical Oncology Hematology Consultants PA
Newark, Delaware, United States, 19713
Actively Recruiting
9
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States, 19718
Actively Recruiting
10
Beebe Health Campus
Rehoboth Beach, Delaware, United States, 19971
Actively Recruiting
11
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States, 19801
Actively Recruiting
12
Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
13
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States, 83706
Actively Recruiting
14
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, United States, 83605
Actively Recruiting
15
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, United States, 83814
Actively Recruiting
16
Idaho Urologic Institute-Meridian
Meridian, Idaho, United States, 83642
Actively Recruiting
17
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, United States, 83687
Actively Recruiting
18
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States, 83854
Actively Recruiting
19
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, United States, 83864
Actively Recruiting
20
Illinois CancerCare-Bloomington
Bloomington, Illinois, United States, 61704
Actively Recruiting
21
Illinois CancerCare-Canton
Canton, Illinois, United States, 61520
Actively Recruiting
22
Memorial Hospital of Carbondale
Carbondale, Illinois, United States, 62902
Actively Recruiting
23
SIH Cancer Institute
Carterville, Illinois, United States, 62918
Actively Recruiting
24
Illinois CancerCare-Carthage
Carthage, Illinois, United States, 62321
Actively Recruiting
25
Centralia Oncology Clinic
Centralia, Illinois, United States, 62801
Actively Recruiting
26
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
27
University of Illinois
Chicago, Illinois, United States, 60612
Actively Recruiting
28
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States, 62526
Actively Recruiting
29
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Actively Recruiting
30
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States, 60115
Actively Recruiting
31
Illinois CancerCare-Dixon
Dixon, Illinois, United States, 61021
Actively Recruiting
32
Crossroads Cancer Center
Effingham, Illinois, United States, 62401
Actively Recruiting
33
Illinois CancerCare-Eureka
Eureka, Illinois, United States, 61530
Actively Recruiting
34
Illinois CancerCare-Galesburg
Galesburg, Illinois, United States, 61401
Actively Recruiting
35
Western Illinois Cancer Treatment Center
Galesburg, Illinois, United States, 61401
Actively Recruiting
36
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States, 60134
Actively Recruiting
37
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States, 60026
Actively Recruiting
38
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States, 60030
Actively Recruiting
39
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, United States, 61443
Actively Recruiting
40
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States, 60045
Actively Recruiting
41
Illinois CancerCare-Macomb
Macomb, Illinois, United States, 61455
Actively Recruiting
42
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States, 62269
Actively Recruiting
43
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, United States, 62269
Actively Recruiting
44
Northwestern Medicine Orland Park
Orland Park, Illinois, United States, 60462
Actively Recruiting
45
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, United States, 61350
Actively Recruiting
46
Illinois CancerCare-Pekin
Pekin, Illinois, United States, 61554
Actively Recruiting
47
Illinois CancerCare-Peoria
Peoria, Illinois, United States, 61615
Actively Recruiting
48
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61636
Actively Recruiting
49
Illinois CancerCare-Peru
Peru, Illinois, United States, 61354
Actively Recruiting
50
Valley Radiation Oncology
Peru, Illinois, United States, 61354
Actively Recruiting
51
Illinois CancerCare-Princeton
Princeton, Illinois, United States, 61356
Actively Recruiting
52
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Actively Recruiting
53
Springfield Clinic
Springfield, Illinois, United States, 62702
Actively Recruiting
54
Memorial Medical Center
Springfield, Illinois, United States, 62781
Actively Recruiting
55
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Actively Recruiting
56
Illinois CancerCare - Washington
Washington, Illinois, United States, 61571
Actively Recruiting
57
Reid Health
Richmond, Indiana, United States, 47374
Actively Recruiting
58
Mercy Hospital
Cedar Rapids, Iowa, United States, 52403
Actively Recruiting
59
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
Actively Recruiting
60
Christiana Care - Union Hospital
Elkton, Maryland, United States, 21921
Actively Recruiting
61
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, United States, 48106
Actively Recruiting
62
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States, 48114
Actively Recruiting
63
Trinity Health Medical Center - Brighton
Brighton, Michigan, United States, 48114
Actively Recruiting
64
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, United States, 48188
Actively Recruiting
65
Trinity Health Medical Center - Canton
Canton, Michigan, United States, 48188
Actively Recruiting
66
Caro Cancer Center
Caro, Michigan, United States, 48723
Actively Recruiting
67
Chelsea Hospital
Chelsea, Michigan, United States, 48118
Actively Recruiting
68
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, United States, 48118
Actively Recruiting
69
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, United States, 48346
Actively Recruiting
70
Newland Medical Associates-Clarkston
Clarkston, Michigan, United States, 48346
Actively Recruiting
71
Henry Ford Health Saint John Hospital
Detroit, Michigan, United States, 48236
Actively Recruiting
72
Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan, United States, 48054
Actively Recruiting
73
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan, United States, 48503
Actively Recruiting
74
Genesee Hematology Oncology PC
Flint, Michigan, United States, 48503
Actively Recruiting
75
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Actively Recruiting
76
Hurley Medical Center
Flint, Michigan, United States, 48503
Actively Recruiting
77
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan, United States, 48236
Actively Recruiting
78
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, United States, 48236
Actively Recruiting
79
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, United States, 48236
Actively Recruiting
80
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, United States, 48912
Actively Recruiting
81
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, United States, 48154
Actively Recruiting
82
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan, United States, 48044
Actively Recruiting
83
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan, United States, 48044
Actively Recruiting
84
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan, United States, 48453
Actively Recruiting
85
Hope Cancer Center
Pontiac, Michigan, United States, 48341
Actively Recruiting
86
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan, United States, 48341
Actively Recruiting
87
Newland Medical Associates-Pontiac
Pontiac, Michigan, United States, 48341
Actively Recruiting
88
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, United States, 48341
Actively Recruiting
89
MyMichigan Medical Center Saginaw
Saginaw, Michigan, United States, 48601
Actively Recruiting
90
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan, United States, 48604
Actively Recruiting
91
MyMichigan Medical Center Tawas
Tawas City, Michigan, United States, 48764
Actively Recruiting
92
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan, United States, 48093
Actively Recruiting
93
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan, United States, 48093
Actively Recruiting
94
Saint John Macomb-Oakland Hospital
Warren, Michigan, United States, 48093
Actively Recruiting
95
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan, United States, 48661
Actively Recruiting
96
Huron Gastroenterology PC
Ypsilanti, Michigan, United States, 48106
Actively Recruiting
97
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, United States, 48197
Actively Recruiting
98
Minnesota Oncology - Burnsville
Burnsville, Minnesota, United States, 55337
Actively Recruiting
99
Cambridge Medical Center
Cambridge, Minnesota, United States, 55008
Actively Recruiting
100
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
101
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Actively Recruiting
102
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, United States, 55369
Actively Recruiting
103
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, United States, 55109
Actively Recruiting
104
Saint John's Hospital - Healtheast
Maplewood, Minnesota, United States, 55109
Actively Recruiting
105
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
106
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
107
Health Partners Inc
Minneapolis, Minnesota, United States, 55454
Actively Recruiting
108
Monticello Cancer Center
Monticello, Minnesota, United States, 55362
Actively Recruiting
109
New Ulm Medical Center
New Ulm, Minnesota, United States, 56073
Actively Recruiting
110
Fairview Northland Medical Center
Princeton, Minnesota, United States, 55371
Actively Recruiting
111
North Memorial Medical Health Center
Robbinsdale, Minnesota, United States, 55422
Actively Recruiting
112
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
113
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
114
United Hospital
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
115
Saint Francis Regional Medical Center
Shakopee, Minnesota, United States, 55379
Actively Recruiting
116
Lakeview Hospital
Stillwater, Minnesota, United States, 55082
Actively Recruiting
117
Ridgeview Medical Center
Waconia, Minnesota, United States, 55387
Actively Recruiting
118
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
Actively Recruiting
119
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, United States, 55125
Actively Recruiting
120
Fairview Lakes Medical Center
Wyoming, Minnesota, United States, 55092
Actively Recruiting
121
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
122
Saint Francis Medical Center
Cape Girardeau, Missouri, United States, 63703
Actively Recruiting
123
Southeast Cancer Center
Cape Girardeau, Missouri, United States, 63703
Actively Recruiting
124
Parkland Health Center - Farmington
Farmington, Missouri, United States, 63640
Actively Recruiting
125
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, United States, 63670
Actively Recruiting
126
Missouri Baptist Medical Center
St Louis, Missouri, United States, 63131
Actively Recruiting
127
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, United States, 63080
Actively Recruiting
128
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, United States, 63127
Actively Recruiting
129
Community Hospital of Anaconda
Anaconda, Montana, United States, 59711
Actively Recruiting
130
Billings Clinic Cancer Center
Billings, Montana, United States, 59101
Actively Recruiting
131
Bozeman Health Deaconess Hospital
Bozeman, Montana, United States, 59715
Actively Recruiting
132
Benefis Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Actively Recruiting
133
Great Falls Clinic
Great Falls, Montana, United States, 59405
Actively Recruiting
134
Kalispell Regional Medical Center
Kalispell, Montana, United States, 59901
Actively Recruiting
135
Community Medical Center
Missoula, Montana, United States, 59804
Actively Recruiting
136
Nebraska Medicine-Bellevue
Bellevue, Nebraska, United States, 68123
Actively Recruiting
137
Nebraska Medicine-Village Pointe
Omaha, Nebraska, United States, 68118
Actively Recruiting
138
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
139
Indu and Raj Soin Medical Center
Beavercreek, Ohio, United States, 45431
Actively Recruiting
140
Saint Elizabeth Boardman Hospital
Boardman, Ohio, United States, 44512
Actively Recruiting
141
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, United States, 45459
Actively Recruiting
142
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, United States, 45236
Actively Recruiting
143
Dayton Physician LLC - Englewood
Dayton, Ohio, United States, 45415
Actively Recruiting
144
Armes Family Cancer Center
Findlay, Ohio, United States, 45840
Actively Recruiting
145
Blanchard Valley Hospital
Findlay, Ohio, United States, 45840
Actively Recruiting
146
Orion Cancer Care
Findlay, Ohio, United States, 45840
Actively Recruiting
147
Dayton Physicians LLC-Atrium
Franklin, Ohio, United States, 45005
Actively Recruiting
148
Dayton Physicians LLC-Wayne
Greenville, Ohio, United States, 45331
Actively Recruiting
149
Wayne Hospital
Greenville, Ohio, United States, 45331
Actively Recruiting
150
Greater Dayton Cancer Center
Kettering, Ohio, United States, 45409
Actively Recruiting
151
Kettering Medical Center
Kettering, Ohio, United States, 45429
Actively Recruiting
152
Dayton Physicians LLC - Troy
Troy, Ohio, United States, 45373
Actively Recruiting
153
Saint Joseph Warren Hospital
Warren, Ohio, United States, 44484
Actively Recruiting
154
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio, United States, 44501
Actively Recruiting
155
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
156
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, United States, 97814
Actively Recruiting
157
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, United States, 97914
Actively Recruiting
158
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
159
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, United States, 18017
Actively Recruiting
160
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, United States, 19317
Actively Recruiting
161
Pocono Medical Center
East Stroudsburg, Pennsylvania, United States, 18301
Actively Recruiting
162
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, United States, 18201
Actively Recruiting
163
The West Clinic - Wolf River
Germantown, Tennessee, United States, 38138
Actively Recruiting
164
MD Anderson in The Woodlands
Conroe, Texas, United States, 77384
Actively Recruiting
165
Lyndon Baines Johnson General Hospital
Houston, Texas, United States, 77026-1967
Actively Recruiting
166
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
167
MD Anderson West Houston
Houston, Texas, United States, 77079
Actively Recruiting
168
MD Anderson League City
League City, Texas, United States, 77573
Actively Recruiting
169
MD Anderson in Sugar Land
Sugar Land, Texas, United States, 77478
Actively Recruiting
170
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, United States, 23235
Actively Recruiting
171
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
172
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, United States, 54017
Actively Recruiting
173
Billings Clinic-Cody
Cody, Wyoming, United States, 82414
Actively Recruiting
174
Welch Cancer Center
Sheridan, Wyoming, United States, 82801
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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