Actively Recruiting
Tezspire Cardiac Events PASS
Led by AstraZeneca · Updated on 2026-05-11
16640
Participants Needed
4
Research Sites
193 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
I
IQVIA Pvt. Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to evaluate the risk of serious adverse cardiovascular events in adolescent and adult patients with severe asthma taking tezepelumab compared to a population receiving standard of care treatment for severe asthma.
CONDITIONS
Official Title
Tezspire Cardiac Events PASS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a diagnosis of asthma receiving tezepelumab or high-intensity standard of care treatment for severe asthma at any point during the study inclusion period.
You will not qualify if you...
- Less than 12 months of data availability prior to index date.
- Age under 12 years at index date.
- History of congenital heart disease or heart transplant.
- Presence of non-fatal myocardial infarction or stroke in the 180 days prior to index date.
- Exposure to non-tezepelumab biologics on index date or within the 5-half-life clearance period of the biologic for comparative analysis.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Healthcare Integrated Research Database (HIRD)
Wilmington, Delaware, United States, 19801
Actively Recruiting
2
Danish registries (access/analysis)
Copenhagen, Denmark
Actively Recruiting
3
French National Health Data System (SNDS)
Paris, France
Actively Recruiting
4
Team Gesundheit GKV Claims data (SHI)
Berlin, Germany
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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