Actively Recruiting
THC Effects on Glucose in Type 2 Diabetes
Led by University of California, San Diego · Updated on 2025-05-07
30
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
C
Center for Medicinal Cannabis Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose metabolism. These tests will be performed prior to start of treatment and again after 2-weeks of treatment with the THC or placebo.
CONDITIONS
Official Title
THC Effects on Glucose in Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 21 to 70 years at screening
- Females of non-childbearing potential must be at least 1 year post-menopausal or surgically sterile
- Females of childbearing potential must agree to use two forms of contraception during the study
- Males must agree to use an acceptable method of contraception during the study
- Clinical diagnosis of Type 2 Diabetes with stable medication regimen for at least 3 months
- Body mass index greater than 25 kg/m2
- HbA1c less than 10%
- Negative urine toxicology at screening
- Able to provide written informed consent approved by an Institutional Review Board
You will not qualify if you...
- History or presence of significant illness increasing risk of adverse events (e.g., psychotic disorder, mood or anxiety disorder, liver or kidney disease)
- Prior history of myocardial infarction, stroke, or heart failure
- Whole blood donation of 500 mL or more within 8 weeks before screening
- Hemoglobin less than 9 g/dL
- Liver enzymes twice the normal limit or clinical signs of liver disease
- History of severe adverse events related to cannabis intoxication
- History of seizures, head trauma, or central nervous system conditions predisposing to seizures
- Use of THC products within 30 days before screening
- Current tobacco use
- Pregnant or breastfeeding individuals
- Current use of insulin for Type 2 Diabetes
- Unable or unwilling to follow study protocol or attend visits
- Any other condition that might affect study data or participant safety or informed consent ability
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UC San Diego Altman Clinical & Translational Research Institute
La Jolla, California, United States, 92037
Actively Recruiting
Research Team
T
Todd May, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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