Actively Recruiting
Therapeutic Drug Monitoring of Brodalumab in Psoriasis Patients (BIOLOPTIM-BRO)
Led by University Hospital, Ghent · Updated on 2024-09-19
100
Participants Needed
7
Research Sites
315 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Ghent
Lead Sponsor
K
KU Leuven
Collaborating Sponsor
AI-Summary
What this Trial Is About
Biologics, such as brodalumab, are currently the most effective treatment option for patients with moderate-to-severe psoriasis. But they are costly for health care systems and prescribed according to a 'one dose fits all' dosing regimen, leading to potential over- and undertreatment. Within this study we aim to investigate the predictive value of early serum trough levels of brodalumab and determine the therapeutic window of brodalumab in psoriasis patients.
CONDITIONS
Official Title
Therapeutic Drug Monitoring of Brodalumab in Psoriasis Patients (BIOLOPTIM-BRO)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have a clinical or histological diagnosis of chronic plaque-type psoriasis
- Participants must sign an informed consent form indicating understanding of the study and willingness to participate
You will not qualify if you...
- Participants with a predominant nonplaque form of psoriasis
- Participants who are pregnant, nursing, or planning a pregnancy
- Participants unable or unwilling to undergo multiple blood draws
- Participants treated with a brodalumab dosing schedule different from the standard
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
AZ Maria Middelares
Ghent, Oost-Vlaanderen, Belgium, 9000
Not Yet Recruiting
2
AZ Sint-Lucas
Ghent, Oost-Vlaanderen, Belgium, 9000
Not Yet Recruiting
3
University Hospital of Ghent
Ghent, Oost-Vlaanderen, Belgium, 9000
Actively Recruiting
4
Private Practice Dermatology
Maldegem, Oost-Vlaanderen, Belgium, 9990
Not Yet Recruiting
5
University Hospital
Leuven, Vlaams-Brabant, Belgium, 3000
Not Yet Recruiting
6
AZ Sint-Jan
Bruges, West-Vlaanderen, Belgium, 8000
Not Yet Recruiting
7
AZ Delta Rembert
Torhout, West-Vlaanderen, Belgium, 8820
Not Yet Recruiting
Research Team
J
Jo Lambert, Prof.
CONTACT
L
Lynda Grine, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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