Comparing Curcumin Nanogels and 0.1% Fluocinolone Acetonide Paste for Treating Atrophic-Erosive Oral Lichen Planus

What this Trial Is About

Researchers are studying oral lichen planus OLP, a chronic inflammatory condition that causes painful mouth sores and affects quality of life. This clinical trial compares the effects of curcumin delivered in nanogels, a natural anti-inflammatory treatment with improved absorption, to the standard corticosteroid treatment using 0.1% fluocinolone acetonide oral paste. The goal is to see if curcumin nanogels can provide similar relief with fewer side effects. Participants will be randomly assigned to one of two groups one applying curcumin nanogels three times daily for four weeks, and the other applying 0.1% fluocinolone acetonide oral paste on the same schedule. Both treatments target affected areas in the mouth. This double-blind trial ensures neither participants nor researchers know which treatment is given to maintain unbiased results. During the study, researchers will assess changes in the severity of oral lichen planus lesions using the Oral Lichen Planus Disease Activity Scale OLP-DAS at the start, two weeks, and four weeks. Participants will also complete a satisfaction questionnaire after four weeks of treatment. The total participation lasts four weeks, focusing on treatment effects and patient experience under monitored conditions.

The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus