Actively Recruiting
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
Led by Chulalongkorn University · Updated on 2026-03-06
30
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.
CONDITIONS
Official Title
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Ability to provide written informed consent
- Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus
- Presence of symptoms with pain score greater than 0 at baseline
- Ability to communicate and follow instructions
- Willingness to apply oral paste treatment and follow the study protocol
You will not qualify if you...
- Pregnancy or breastfeeding
- Current orthodontic treatment
- Uncontrolled diabetes mellitus (HbA1c > 7% or fasting plasma glucose > 130 mg/dL)
- Use of anticoagulant or antiplatelet medications
- Severe dry mouth (Challacombe score > 7)
- History of gastric ulcers, duodenal ulcers, or gallstones
- Presence of any active cancer or infection
- Use of topical or systemic treatment for oral lichen planus in the past 2 weeks
- Current use of immunosuppressant medications
- Known allergy to corticosteroids or herbal agents such as turmeric
- Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)
- History of allogeneic bone marrow transplantation
- Current smoker
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Dentistry, Chulalongkorn University
Bangkok, Thailand, 10400
Actively Recruiting
Research Team
T
Tossapol Maneethorn, D.D.S.
CONTACT
P
Pirawish Limlawan, D.D.S., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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