Actively Recruiting
TheRapeutic Effect of Different immunosuppressAnts on Non-Thymoma Ocular Myasthenia Gravis: a Real-world Study
Led by Tang-Du Hospital · Updated on 2026-01-30
200
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study collects the clinical data of new-onset ocular myasthenia gravis (OMG) patients, assesses outcomes and adverse effects of different treatment options, and evaluate risk factors of conversion to generalized MG(GMG).
CONDITIONS
Official Title
TheRapeutic Effect of Different immunosuppressAnts on Non-Thymoma Ocular Myasthenia Gravis: a Real-world Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years and less than 75 years
- Clinical diagnosis of myasthenia gravis with ocular muscle symptoms only, without other clinical symptoms
- Patients must meet at least one of the following: clear response to pyridostigmine; positive acetylcholine receptor or musk antibodies; more than 10% decrement in nerve stimulation test; broadened trembling in single fiber electromyography
- Willingness to undergo sample collection, imaging, and other disease-related tests
- Negative pregnancy test for females of childbearing potential and use of effective contraception during the study
- Signed informed consent
- Predicted survival time longer than 3 years
You will not qualify if you...
- History of other chronic degenerative, psychiatric, or neurological disorders causing weakness or fatigue
- Presence of other diseases causing eyelid drooping, muscle weakness, or double vision
- Age 18 years or younger, or 75 years or older
- Prior treatment with glucocorticoids or immunosuppressants for other immune diseases
- Inability to use immunosuppressants due to other chronic illnesses
- Severe mental illness or cognitive impairment preventing cooperation with follow-up
- Pregnancy, breastfeeding, or plans for pregnancy during the study
- Recent severe infections or cancers preventing immunosuppressive treatment
- Unwillingness to undergo repeated nerve stimulation tests or chest CT scans
- Unwillingness to participate in the study
- Inability to provide informed consent
- Predicted survival time less than 3 years
- Deemed unsuitable for the trial by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tangdu Hospotal
Xi'an, Shaanxi, China
Actively Recruiting
Research Team
J
Jun Guo, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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