Study of Treatment Options for Large Ovarian Endometrioma in Women Aged 18 to 40

What this Trial Is About

Large ovarian endometriomas, which occur in 23 to 55% of cases, can cause pelvic pain, reduced fertility, and decreased ovarian reserve. There is currently no established best treatment to limit recurrence, preserve fertility, and maintain ovarian reserve. Researchers at Lille University Hospital are evaluating a protocol involving laparoscopic drainage combined with hormonal therapy for women of childbearing age with endometriomas measuring 6 cm or larger. This observational and prospective study focuses on women aged 18 to 40 with large endometriomas. The treatment being studied is cyst drainage followed by a GnRH agonist hormone therapy. The aim is to assess if this approach can reduce cyst recurrence, protect ovarian reserve, and evaluate effects on anti-Mllerian hormone levels. Participants will be monitored to measure the recurrence rate of cysts 3 cm or larger at 3 months using MRI or pelvic ultrasound. Researchers will also evaluate postoperative ovarian reserve and track the number of re-operations by 4 months. The study involves clinical imaging and hormone tests to understand treatment impact over the follow-up period.

The Therapy of Large Endometrioma