Actively Recruiting
Therapy Optimisation for the Treatment of Hairy Cell Leukemia
Led by University of Giessen · Updated on 2024-08-22
210
Participants Needed
76
Research Sites
1230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The trial will test the effectiveness and toxicity of subcutaneous treatment with one cycle of cladribine in patients with hairy cell leukemia requiring treatment. They have to be untreated so far or may be pretreated with alpha-interferon.
CONDITIONS
Official Title
Therapy Optimisation for the Treatment of Hairy Cell Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with histologically verified hairy cell leukemia
- Presence of hairy cells in bone marrow and peripheral blood detected by TRAP staining and/or co-expression of CD19/CD25 or CD19/CD103
- No previous cytostatic treatment (splenectomy or interferon treatment allowed)
- Need for treatment
- Age at least 18 years old
- General health status WHO 0-2
- Current histology not older than 6 months
- Written consent provided
You will not qualify if you...
- Patients not meeting inclusion criteria
- Hairy cell leukemia variants with intermediate morphology and negative TRAP staining
- Prior treatment with purine analogues or other chemotherapy
- Concurrent corticosteroid therapy
- Severe heart dysfunction (NYHA III or IV), severe lung disease (WHO Grade III or IV), liver or kidney dysfunction as specified
- Central nervous system diseases including psychoses
- Proven HIV infection
- Active hepatitis or other active infections
- History or diagnosis of other malignant diseases except specified skin tumors or stage 0 cervical carcinoma
- Pregnant or lactating women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 76 locations
1
Community based hemato-oncology medical office
Ansbach, Germany, 91522
Actively Recruiting
2
Community based hemato-oncology medical office
Aschaffenburg, Germany, 63739
Actively Recruiting
3
Rhön-Saale-Klinik gGmbH
Bad Neustadt an der Saale, Germany, 97616
Actively Recruiting
4
Community based hemato-oncology medical office
Berlin, Germany, 10407
Actively Recruiting
5
Charité - Universitätsmedizin Berlin
Berlin, Germany, 12203
Actively Recruiting
6
Community based hemato-oncology medical office
Bremen, Germany, 28209
Actively Recruiting
7
Community based hemato-oncology medical office
Celle, Germany, 29221
Actively Recruiting
8
Community based hemato-oncology medical office
Cottbus, Germany, 03046
Actively Recruiting
9
Community based hemato-oncology medical office
Darmstadt, Germany, 64295
Actively Recruiting
10
Community based hemato-oncology medical office
Dresden, Germany, 01127
Actively Recruiting
11
Community based hemato-oncology medical office
Duisburg, Germany, 47166
Actively Recruiting
12
Klinik Duisburg-West
Duisburg, Germany, 47228
Actively Recruiting
13
Universitätsklinik Düsseldorf
Düsseldorf, Germany, 40255
Actively Recruiting
14
Community based hemato-oncology medical office
Ehingen, Germany, 89584
Actively Recruiting
15
Community based hemato-oncology medical office
Erlangen, Germany, 91052
Actively Recruiting
16
Community based hemato-oncology medical office
Frankfurt, Germany, 60389
Actively Recruiting
17
Krankenhaus Nordwest
Frankfurt, Germany, 60488
Actively Recruiting
18
Community based hemato-oncology medical office
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
19
Community based hemato-oncology medical office
Friedrichshafen, Germany, 88045
Actively Recruiting
20
Community based hemato-oncology medical office
Fürth, Germany, 90766
Actively Recruiting
21
Community based hemato-oncology medical office
Germering, Germany, 82110
Actively Recruiting
22
Community based hemato-oncology medical office
Giessen, Germany, 35392
Actively Recruiting
23
University Clinic | Medicinal Clinic IV
Giessen, Germany, 35592
Actively Recruiting
24
St.-Marien-Hospital
Hagen, Germany, 58095
Actively Recruiting
25
Community based hemato-oncology medical office
Halle, Germany, 06110
Actively Recruiting
26
Evangelisches Krankenhaus
Hamm, Germany, 59063
Actively Recruiting
27
Community based hemato-oncology medical office
Hanau, Germany, 63450
Actively Recruiting
28
Community based hemato-oncology medical office
Heidelberg, Germany, 69115
Actively Recruiting
29
Community based hemato-oncology medical office
Herne, Germany, 44623
Actively Recruiting
30
Marienkrankenhaus
Herne, Germany, 44625
Actively Recruiting
31
Community based hemato-oncology medical office
Homberg (Ohm), Germany, 34576
Actively Recruiting
32
Community based hemato-oncology medical office
Kaiserslautern, Germany, 67655
Actively Recruiting
33
Städtisches Klinikum
Karlsruhe, Germany, 76137
Actively Recruiting
34
Community based hemato-oncology medical office
Kassel, Germany, 34117
Actively Recruiting
35
Klinikum Kempten-Oberallgäu
Kempten, Germany, 87439
Actively Recruiting
36
Community based hemato-oncology medical office
Koblenz, Germany, 56068
Not Yet Recruiting
37
Community based hemato-oncology medical office
Krefeld, Germany, 47798
Actively Recruiting
38
Community based hemato-oncology medical office
Kronach, Germany, 96317
Actively Recruiting
39
Community based hemato-oncology medical office
Landau, Germany, 76829
Actively Recruiting
40
Community based hemato-oncology medical office
Landshut, Germany, 84028
Actively Recruiting
41
Community based hemato-oncology medical office
Landshut, Germany, 84034
Actively Recruiting
42
Klinikum Leverkusen GmbH
Leverkusen, Germany, 51375
Actively Recruiting
43
St. Marienkrankenhaus
Ludwigshafen, Germany, 67067
Actively Recruiting
44
Community based hemato-oncology medical office
Lüdenscheid, Germany, 58507
Actively Recruiting
45
Universitätsklinik Mainz
Mainz, Germany, 55131
Actively Recruiting
46
Community based hemato-oncology medical office
Marburg, Germany, 35037
Actively Recruiting
47
Community based hemato-oncology medical office
Mönchengladbach, Germany, 41239
Actively Recruiting
48
Community based hemato-oncology medical office
München, Germany, 80335
Actively Recruiting
49
University Clinic Großhadern
München, Germany, 81377
Actively Recruiting
50
Community based hemato-oncology medical office
Neumarkt, Germany, 92318
Actively Recruiting
51
Community based hemato-oncology medical office
Nuremberg, Germany, 90403
Actively Recruiting
52
Community based hemato-oncology medical office
Nuremberg, Germany, 90449
Actively Recruiting
53
St. Clemens Hospital
Oberhausen, Germany, 46145
Actively Recruiting
54
St. Martinus-Hospital
Olpe, Germany, 57462
Actively Recruiting
55
Community based hemato-oncology medical office
Osnabrück, Germany, 49074
Actively Recruiting
56
St. Josefs-Krankenhaus
Potsdam, Germany, 14471
Actively Recruiting
57
Community based hemato-oncology medical office
Rehling, Germany, 86508
Actively Recruiting
58
Community based hemato-oncology medical office
Rüsselsheim am Main, Germany, 65428
Actively Recruiting
59
Caritas Klinik St. Theresia
Saarbrücken, Germany, 66113
Actively Recruiting
60
Community based hemato-oncology medical office
Schkeuditz, Germany, 04435
Actively Recruiting
61
Kreiskrankenhaus Schotten
Schotten, Germany, 63679
Actively Recruiting
62
Community based hemato-oncology medical office
Schweinfurt, Germany, 97421
Actively Recruiting
63
Community based hemato-oncology medical office
Siegen, Germany, 57072
Actively Recruiting
64
St.-Marien-Krankenhaus
Siegen, Germany, 57072
Actively Recruiting
65
Diakonie - Klinikum Stuttgart
Stuttgart, Germany, 70176
Actively Recruiting
66
Community based hemato-oncology medical office
Trier, Germany, 54290
Actively Recruiting
67
Community based hemato-oncology medical office
Tübingen, Germany, 72072
Actively Recruiting
68
University Clinic Ulm
Ulm, Germany, 89081
Actively Recruiting
69
Städtisches Krankenhaus Villingen
Villingen-Schwenningen, Germany, 78050
Actively Recruiting
70
Community based hemato-oncology medical office
Weilheim, Germany, 82362
Actively Recruiting
71
Sophien- und Hufeland Klinikum
Weimar, Germany, 99425
Actively Recruiting
72
Asklepios Nordseeklinik
Westerland, Germany, 25980
Actively Recruiting
73
Community based hemato-oncology medical office
Wiesbaden, Germany, 65191
Actively Recruiting
74
Dr. Horst-Schmidt-Kliniken
Wiesbaden, Germany, 65199
Actively Recruiting
75
Community based hemato-oncology medical office
Wilhelmshaven, Germany, 26389
Actively Recruiting
76
Community based hemato-oncology medical office
Wolfsburg, Germany, 38440
Actively Recruiting
Research Team
M
Mathias J Rummel, Prof PhD
CONTACT
J
Juergen Barth
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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