Actively Recruiting
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Led by ART Fertility Clinics LLC · Updated on 2025-02-19
70
Participants Needed
1
Research Sites
239 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected. Most patients already had impaired or complete loss of fecundity when diagnosed. Hence, the treatment of POI is particularly tough. Currently, no optimal regimen exists to ameliorate ovarian function.
CONDITIONS
Official Title
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent
- Women 40 years of age and younger with documented primary ovarian insufficiency
- Normal karyotype
- BMI less than or equal to 35 kg/m2
- Oligo/amenorrhea for at least 4 months
- FSH greater than 25 IU/mL
- AMH less than or equal to 0.1 ng/ml
- No evidence of follicles larger than 4 mm
- Must have two ovaries of approximately equal volume
- Willingness to undergo further fertility treatment, including IVF if response is seen
- Undergoing a transvaginal scan including Doppler for ovarian artery before surgery
You will not qualify if you...
- Premature ovarian failure due to genetic causes like Turner's syndrome or chromosomal abnormalities
- Current oncological diseases, especially affecting bones or blood
- Autoimmune diseases such as lupus erythematosus
- Previous radiotherapy or chemotherapy treatments
- Conditions unsuitable for surgery or anesthesia
- Receiving anticoagulant or antiaggregant treatment
- Acute or chronic infectious diseases
- Active substance abuse or dependence
- Major mental health disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates, 60202
Actively Recruiting
Research Team
B
barbara Lawrenz, PhD
CONTACT
J
Jonalyn Edades
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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