Actively Recruiting
Thermogenenic Responses to Fasting and Overfeeding in Women
Led by University of Colorado, Denver · Updated on 2025-04-30
56
Participants Needed
1
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain. The weight gained is primarily body fat, particularly visceral or abdominal body fat. The excess gain in abdominal fat during menopause increases the risk of chronic metabolic diseases such as heart disease and diabetes. The increase in weight and body fat with menopause may be due to changes in metabolism related to the loss of estrogen. This study plans to compare how the metabolism of premenopausal and postmenopausal women responds to changes in energy intake. The investigators will compare the changes in energy expenditure that occur during a period of acute fasting (24 hours) and a period of consuming excess calories (overfeeding).
CONDITIONS
Official Title
Thermogenenic Responses to Fasting and Overfeeding in Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premenopausal women aged 18 to 45 years with regular menstrual cycles (no missed cycles in the past year and cycle length 25-35 days)
- Postmenopausal women with no menstrual periods for at least 12 months and follicular stimulating hormone (FSH) levels �3750 mIU/ml
- Women within 2 years of their final menstrual period are preferred
You will not qualify if you...
- Body mass index greater than 30 kg/m2
- Diabetes with fasting glucose greater than 126 mg/dL
- Thyroid dysfunction with thyroid stimulating hormone (TSH) less than 0.5 or greater than 5.0 mU/L unless treated and stable
- Uncontrolled hypertension with resting systolic blood pressure over 150 mmHg or diastolic over 90 mmHg unless treated and stable
- Postmenopausal women with history or current use of estrogen-based hormonal therapy
- Postmenopausal women who have had surgical menopause
- Premenopausal women currently using hormonal contraceptives or used them within the past 6 months
- Premenopausal women who are pregnant, breastfeeding, or planning to become pregnant during the study period
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
E
Edward L Melanson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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