Actively Recruiting
Thermotherapy in Addition to SOC Palliative Radiotherapy
Led by King's College London · Updated on 2025-12-22
60
Participants Needed
2
Research Sites
176 weeks
Total Duration
On this page
Sponsors
K
King's College London
Lead Sponsor
G
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate the efficacy and safety profile of superficial hyperthermia (wIRA) in addition to standard of care (SOC) palliative radiotherapy in patients with inoperable/incurable locally advanced or recurrent/metastatic HNSCC or cutaneous SCC superficial tumours not suitable for radical treatment. The investigators will assess the best objective response rate (ORR) of patients with Inoperable/incurable or recurrent/metastatic HNSCC or cSCC with superficial lesion(s) treated with the combination of superficial hyperthermia (wIRA) and palliative radiotherapy.
CONDITIONS
Official Title
Thermotherapy in Addition to SOC Palliative Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient with histologically confirmed incurable or inoperable cancers with disease [at least one superficial lesion(s) or lymph node(s)] suitable for hydrosun4 TWH1500 treatment
- Patient undergoing standard of care palliative radiotherapy (suitable with the pre-specified dose and fractionation in the protocol)
- Aged 6518 years old
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
- Patient with capacity to consent
You will not qualify if you...
- No superficial tumour lesion or lymph node that is suitable for hydrosun4 TWH1500 treatment
- Patients are not suitable for one of the pre-specified palliative radiotherapy dose and fractionation
- Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Guy's and St. Thomas NHS Foundation Trust
London, United Kingdom, SE1 9RT
Actively Recruiting
2
Guy's Cancer Centre
London, United Kingdom
Actively Recruiting
Research Team
A
Anthony Kong
CONTACT
T
Taylor McKenzie
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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