Actively Recruiting
Thiamine Intervention and Coronary Artery Bypass Grafting
Led by University of California, Los Angeles ยท Updated on 2025-08-01
52
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.
CONDITIONS
Official Title
Thiamine Intervention and Coronary Artery Bypass Grafting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with Coronary Heart Disease (CHD) scheduled for Bypass Grafting (CABG)
- Thiamine deficiency before CABG
- European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) >1.5%
- Off-pump surgery
- Age between 60 and 80 years
You will not qualify if you...
- Dementia at baseline (Montreal Cognitive Assessment (MoCA) <21 within 5 days before CABG)
- Current intake of thiamine
- Known thiamine allergy
- Uncontrolled blood glucose levels
- Unable to give consent due to illness
- History of hyperlactatemia
- Recent cerebral incidents such as seizure or head trauma with loss of consciousness/concussion
- Stroke
- Diagnosed psychiatric diseases (clinical depression, schizophrenia, manic-depression)
- History of alcohol or substance abuse
- Acute or chronic infections (tuberculosis, hepatitis, or encephalopathy)
- Diagnosed neuro-degenerative diseases (Alzheimer's or Parkinson's disease)
- Chronic immunodeficiency (including HIV)
- Congenital brain deficits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
R
Rajesh Kumar, PhD
CONTACT
D
Dineth Karunamuni, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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