Actively Recruiting
Third Party Viral Specific T-cells (VSTs)
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2025-12-16
750
Participants Needed
4
Research Sites
639 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.
CONDITIONS
Official Title
Third Party Viral Specific T-cells (VSTs)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Immunocompromised patient with evidence of viral infection or reactivation
- Age greater than 1 day
- For stem cell transplant recipients, at least 21 days have passed since stem cell infusion
- Clinical status allows tapering of steroids to less than 0.5 mg/kg prednisone or equivalent
- Must be able to receive CTL infusion in Cincinnati
- Informed consent obtained by PI or sub-investigator in person or by phone
You will not qualify if you...
- Active acute graft-versus-host disease grades II-IV
- Uncontrolled bacterial or fungal infection
- Uncontrolled relapse of malignancy requiring chemotherapy
- Infusion of ATG or alemtuzumab within 2 weeks before VST infusion
- Biopsy-confirmed acute rejection of solid organ transplant or empiric treatment for suspected acute rejection within the last 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Akron Children's Hospital
Akron, Ohio, United States, 44308
Actively Recruiting
2
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Completed
3
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
4
The Ohio State University Wexner Medical Center - James Cancer Hospital
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
J
Jamie Wilhelm
CONTACT
M
Michael Grimley, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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