Actively Recruiting
THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-04-28
120
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Allergic and inflammatory conditions have been increasing over the years. Many factors may play a role in this. Every day, people are exposed to pollution and chemicals in our foods, clothing, and all of the cleaning, hygiene, and other products we use. Studies have suggested there may be links between these environmental exposures and allergic and inflammatory illnesses. Researchers want to know more about how these exposures affect our health. Objective: To learn how everyday exposure to common substances affects people s health. Eligibility: Healthy people aged 18 to 80 years. Design: Participants will have 2 stays in the hospital. Each stay will last 7 days, and the stays will be spaced 4 to 6 weeks apart. During both stays, participants will remain confined to their room. They will eat only food from the menu, and they will use only provided products for personal care. (They may bring their own electronic devices, such as their phone and computer.) One stay will be in a pure room. Participants will breathe filtered air, eat unprocessed foods, and use personal care products with fewer chemicals. One stay will be in a room that allows exposure to common environmental chemicals. Some participants will be limited to only 1 type of exposure: chemicals thought to affect only skin, gut, or respiratory health. Some participants will be exposed to all 3 types. Participants will undergo testing. Blood, skin cell, urine, mouth swabs, and stool samples will be taken. They will have lung tests, smell tests, and tests that measure the health of their skin. These tests will be repeated in outpatient visits 2 weeks after each hospital stay....
CONDITIONS
Official Title
THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent
- Age 18 to 80 years
- Agreement to follow lifestyle considerations
- Ability to exclusively adhere to unprocessed and minimally processed diets during inpatient stays
- Ability to speak English
- Willingness to allow storage of samples and data for future research
You will not qualify if you...
- Diagnosis of atopic conditions (asthma, atopic dermatitis, food allergy, chronic hives), autoimmune, metabolic, chronic infectious, or inflammatory diseases
- Positive Phadiatop allergy test
- History of cancer within the past 5 years
- Use of medications affecting skin, gut, or airway symptoms including recent antibiotics (3-6 months), corticosteroids (within 1 month), or chemotherapy
- Current chemotherapy treatment
- HIV, hepatitis B, or hepatitis C infection
- Receipt of any vaccine within 1 month prior to enrollment
- Participation in another treatment or intervention study within 3 months prior to enrollment
- Currently pregnant or breastfeeding
- Currently smoking or vaping
- Any other condition or illness considered a risk by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
J
Jodi L Blake, R.N.
CONTACT
H
Hirsh D Komarow, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here