Actively Recruiting
Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2025-12-08
100
Participants Needed
1
Research Sites
480 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.
CONDITIONS
Official Title
Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years and over
- Severe eye dryness grade 3 or 4 as defined by International Dry Eye Work Shop (2007) with frequent symptoms
- Fluorescein impregnation at the conjunctival level and marked staining at the corneal level
- Tear Break Up Time 64 5 seconds (fluorescein test)
- Schirmer's test score without anesthesia 64 5mm at 5 minutes
- Patients without eye treatment or on long-term stable eye treatment starting a new treatment
- Control subjects aged 18 years and over
You will not qualify if you...
- Known pregnancy or breastfeeding
- Contact lens wearers (control subjects)
- Topical ocular treatment (control subjects)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondation Ophtalmologique A de Rothschild
Paris, France, 75019
Actively Recruiting
Research Team
A
Amélie YAVCHITZ
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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