Actively Recruiting
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
Led by The University of Texas Medical Branch, Galveston · Updated on 2025-12-24
60
Participants Needed
1
Research Sites
187 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Medical Branch, Galveston
Lead Sponsor
T
ThriveWell Cancer Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study's purpose is to evaluate whether creatine supplementation can help breast cancer survivors respond quicker to exercise by improving strength, endurance, and body composition. We are seeking to compare information collected from healthy woman of the same age who have never had breast cancer to those participants who have had breast cancer and undergone chemotherapy treatment.
CONDITIONS
Official Title
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years
- Diagnosis of breast cancer requiring chemotherapy
- Completed chemotherapy within the last 6 months
- Willing to attend 3 virtual exercise sessions per week
- Able to take oral medications
- Able and willing to provide consent
- Serum creatinine less than or equal to 1.5 times the upper limit of normal or estimated glomerular filtration rate (eGFR) of at least 30 mL/min/1.73 m2
- For healthy controls: Age 18 to 75 years
- Never diagnosed with cancer
- Willing to provide consent
You will not qualify if you...
- Physical conditions limiting or contraindicating exercise
- Poorly controlled high blood pressure (greater than 160/95 mmHg)
- Tobacco use within the last 6 months
- Use of anabolic steroids
- Pitting edema greater than 2+
- Currently undergoing chemotherapy treatment
- History of moderate to severe heart disease or pulmonary disease causing shortness of breath with minimal exertion
- Pregnant or planning pregnancy during the study
- Recent or expected corticosteroid treatment (except short term during chemotherapy)
- Serum creatinine greater than 1.5 times the upper limit of normal or eGFR less than 30 mL/min/1.73 m2
- Currently taking creatine supplements
- Lack of access to a smartphone or internet
- For healthy controls: History of cancer diagnosis
- Diagnosed bipolar disorder or neurological disorders
- Uncontrolled diabetes (A1c 6.5% or higher)
- Recent use of appetite stimulants or suppressants
- Taking prescribed medication preparing for pregnancy (e.g., hormonal therapy for IVF)
AI-Screening
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Trial Site Locations
Total: 1 location
1
The University of Texas Medical Branch, Galveston
Galveston, Texas, United States, 77555
Actively Recruiting
Research Team
L
Lisa Thibodeaux, RN,BSN
CONTACT
R
Rebecca Geck, MPH,APRN,CPT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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