Actively Recruiting
THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
Led by Imperial College London · Updated on 2026-04-24
6660
Participants Needed
1
Research Sites
205 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening. Varicose vein procedures may carry a slightly higher risk of blood clot formation, and we are currently unsure if current clot reducing medicines are beneficial in preventing blood clots in people having varicose vein procedures. This study will investigate if it is worthwhile prescribing medicines to reduce blood clots after varicose vein procedures.
CONDITIONS
Official Title
THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults (>18 years)
- Scheduled to undergo endovenous intervention of truncal varicose veins under local anaesthesia
- Treatment technologies including radiofrequency, laser, mechanochemical, foam sclerotherapy and cyanoacrylate glue
You will not qualify if you...
- Clinical indication for therapeutic anticoagulation, such as atrial fibrillation
- Previous personal or first-degree relative history of venous thromboembolism (VTE)
- Thrombophilia
- Female patients of childbearing potential with a positive pregnancy test
- Allergy to heparins or direct oral anticoagulants
- History of heparin-induced thrombocytopenia
- Inherited or acquired bleeding disorders
- Evidence of active bleeding
- Major health problems like active cancer or chronic kidney or liver impairment
- Known thrombocytopenia (platelets less than 50 x 10^9/L)
- Surgery or major trauma within the past 90 days
- Recent ischemic stroke within the past 90 days
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Imperial College Hospital NHS Foundation Trust
London, United Kingdom, W6 8RF
Actively Recruiting
Research Team
S
Sarah Whittley
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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