Actively Recruiting
Thromboprophylaxis in Lower Limb Immobilisation TiLLI Two Linked Phase III Trials Evaluating Medication Effectiveness and Cost for Patients With Temporary Lower Limb Casts or Splints
Led by Queen Mary University of London · Updated on 2026-01-06
10044
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the clinical and cost effectiveness of different methods to prevent blood clots in people who have a leg injury treated with a plaster cast or splint. The study focuses on comparing oral tablets to injections in people at high risk of clots, and also whether any medication is better than advice alone for people at low risk. This is a phase III, multicenter study involving two linked trials called TiLLI-High and TiLLI-Low.
CONDITIONS
Brief Title
Thromboprophylaxis in Lower Limb Immobilisation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 16 years or older
- Currently placed in a temporary lower limb immobilisation (rigid cast or brace) due to an injury within the last 7 days
You will not qualify if you...
- Hospital admission expected to last more than 2 days from emergency or fracture clinic
- Known allergy or contraindication to anticoagulants including severe kidney or liver problems
- Use of certain medications that interact with anticoagulants
- Pregnancy, actively trying to conceive, or breastfeeding
- Use of anticoagulant treatment for more than 3 days before the study
- Previous participation in this study
- Use of non-rigid immobilisation like crepe bandage or strapping
- Immobilisation prescribed more than 3 days ago
- Participation in another clinical trial involving anticoagulants
- Lack of capacity to consent
- Inability or refusal to use contraception if assigned to certain medications and of childbearing potential
Research Team
T
Trial Manager
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