Actively Recruiting
Thrombosis in Diffuse Large B-cell Lymphoma:the PREDIC-TO (PREDICt ThrOmbosis) Study
Led by Fondazione IRCCS San Gerardo dei Tintori · Updated on 2024-11-19
1000
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
F
Fondazione IRCCS San Gerardo dei Tintori
Lead Sponsor
U
University of Milano Bicocca
Collaborating Sponsor
AI-Summary
What this Trial Is About
Comparative Evaluation of Thrombotic Risk Models in DLBCL patients Objective: To assess the impact of thrombotic risk factors and compare the performance of existing predictive models (Khorana, Throly, Model IX) in Diffuse Large B-cell Lymphoma (DLBCL) Primary Endpoints: Measure thrombotic risk factors in existing models Determine occurrence, type, and timing of venous thrombotic events Secondary Endpoints: Assess performance of models in patients without thrombotic events at diagnosis Evaluate dynamic risk factors during DLBCL treatment Identify additional risk factors not included in published models Analyze overall survival and VTE-free survival Methodology: Real-world cohort study of DLBCL patients Collection of static and dynamic risk factors Correlation analysis of risk factors with thrombotic events Development and validation of DLBCL-specific predictive model Conclusion: This study aims to compare existing predictive models and develop a DLBCL-specific model to aid in identifying high-risk patients and inform thromboprophylaxis decisions. Results will contribute to improved understanding and management of thrombotic risk in DLBCL.
CONDITIONS
Official Title
Thrombosis in Diffuse Large B-cell Lymphoma:the PREDIC-TO (PREDICt ThrOmbosis) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged 60; 18 years
- Histological diagnosis of DLBCL
- Informed consent freely given and obtained
You will not qualify if you...
- Active anticoagulant therapy at the time of diagnosis
- Start of prophylactic heparin following diagnosis
- Absence of necessary data to extrapolate risk scores (Khorana, Throly and Model IX) at diagnosis
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ivan Civettini
Monza, Italy, Italy
Actively Recruiting
Research Team
I
IVan Civettini, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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