Actively Recruiting
Thrombosis and Inflammation in Vessels Initiative (TIVI)
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-05-14
1000
Participants Needed
1
Research Sites
479 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Diseases related to the immune system, blood clots, and blood vessels can affect every part of the body. These diseases are now known to be interrelated: People who have strokes, blood clots in their legs, or autoimmune disease, for example, are at greater risk of complications in the heart, brain, and other organs. Researchers want to learn more about how these diseases start, how they change over time, and how they affect different organs. Objective: To learn more about how inflammation and diseases of the blood vessels start and how they change over time. Eligibility: People aged 5 years and older with a disease related to blood clots, the immune system, or blood vessels. Healthy relatives of people with these diseases and unrelated healthy volunteers are also needed. Design: Participants will have a baseline visit: They will provide a medical history, physical exam and blood test. All other tests and procedures are optional; these may be spread over more than 1 day: Tests of heart and lung function. Fill in a family tree form. Imaging scans Treadmill or bike stress tests and a 6-minute walk test. Tests of blood pressure and the flow of blood through vessels. Photos of the face and body. Eye exams, with photos taken of the retina. Saliva and urine samples. Biopsies (tissues samples) of the skin and fat. Tests of thinking and mental function. Evaluations by other medical specialists. Participants may opt to return for repeat testing for up to 90 months (7.5 years). Some visits may be done by telehealth.
CONDITIONS
Official Title
Thrombosis and Inflammation in Vessels Initiative (TIVI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 25 years at the time of consent
- Ability of subject or Legally Authorized Representative (LAR) to understand and willingness to sign a written informed consent document
- Known or possible thrombotic, immune, or vascular disorder (for affected subjects)
- Being a relative of an affected subject (for relatives)
- In good general health as evidenced by medical history (for unrelated healthy controls)
You will not qualify if you...
- Any condition that in the opinion of the Investigator would warrant exclusion
- Unrelated healthy volunteers who decline to have blood drawn and/or tissue studies or do not consent to have samples stored for future research
- Cognitively impaired individuals
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Sandra Cooper Bennett, R.N.
CONTACT
Y
Yogendra Kanthi, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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