Actively Recruiting
The Thrombus Aspiration During PCI After Thrombolysis in STEMI
Led by Shenghua Zhou · Updated on 2026-02-27
3500
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether thrombus aspiration combined with percutaneous coronary intervention (PCI) improves clinical outcomes in ST-segment elevation myocardial infarction (STEMI) patients with high thrombus burden post-thrombolysis, compared to PCI alone. The study population includes 3500 STEMI patients, confirmed by diagnosis, who are transferred to PCI centers after receiving thrombolysis and have no contraindications to thrombolysis.The main questions it aims to answer are: 1. Does thrombus aspiration reduce 30-day major adverse cardiovascular events (MACE), including cardiovascular death, recurrent myocardial infarction, stroke, or heart failure rehospitalization? 2. Can thrombus aspiration improve microcirculation and clinical outcomes for high thrombus burden patients after thrombolysis? Researchers will compare patients randomly assigned to receive thrombus aspiration combined with PCI versus those who receive PCI alone to evaluate the effects on reducing MACE and improving clinical recovery. Participants will: Undergo initial thrombolysis followed by transfer to PCI centers. Be randomly assigned in a 1:1 ratio to receive either thrombus aspiration combined with PCI or PCI alone. Be followed for 30 days post-treatment to assess MACE and other clinical outcomes.
CONDITIONS
Official Title
The Thrombus Aspiration During PCI After Thrombolysis in STEMI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with ST-segment Elevation Myocardial Infarction (STEMI)
- No contraindications for thrombolysis and has received thrombolytic treatment
- Undergoing coronary angiography within 2 to 24 hours after thrombolysis
- Angiography confirms TIMI thrombus load of 4 or higher and residual stenosis greater than 50%
You will not qualify if you...
- Contraindications for thrombolysis
- Presence of cardiogenic shock
- Need for coronary artery bypass grafting
- Age less than 18 years
- Life expectancy less than 6 months
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of General Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle Renmin Road, Changsha, 410011 Hunan, PR China
Changsha, Hunan, China
Actively Recruiting
Research Team
S
Shenghua Zhou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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