Actively Recruiting

Phase Not Applicable
FEMALE
NCT07005349

THUMB: Multi-centre Cluster Trial for Caesarean Section Haemorrhage

Led by Bruce Biccard · Updated on 2026-04-13

2400

Participants Needed

1

Research Sites

56 weeks

Total Duration

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AI-Summary

What this Trial Is About

The quality improvement project evaluating the delivery of a perioperative care complex intervention to improve haemorrhage-related outcomes in patients undergoing caesarean section. The objectives of the current study will be: 1. To evaluate whether implementation of the 'Rule of THUMB' perioperative complex intervention increases risk assessment, diagnosis and compliance with proven interventions for haemorrhage during and after caesarean section. 2. To understand the influence of contextual and socio-dynamic factors on how the trial results were achieved and how the intervention mechanisms did, or did not, work in practice (the process evaluation). The findings from this study will be used subsequently to modify and improve the quality improvement intervention, so that it can be delivered at scale across Africa and assess its impact on haemorrhage during and after caesarean section in the future.

CONDITIONS

Official Title

THUMB: Multi-centre Cluster Trial for Caesarean Section Haemorrhage

Who Can Participate

FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Any patient who requires a caesarean section in participating countries with hospitals that routinely perform caesarean section.
Not Eligible

You will not qualify if you...

  • Patients who opt out of the trial will be excluded.

AI-Screening

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Trial Site Locations

Total: 1 location

1

Mowbray Maternity Hospital

Cape Town, South Africa

Actively Recruiting

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Research Team

M

MARGOT FLINT, PhD

CONTACT

B

BRUCE BICCARD, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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