Preoperative embolization of thyroid arteries in a patient with large multinodular goiter and papillary carcinoma.
Helton Estrela Ramos, Milena Braga-Basaria, Calixto Haquin...
https://pubmed.ncbi.nlm.nih.gov/15671777Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID07360587
Thyroid Artery Embolization for the Treatment of Compressive Goiters: a Prospective Cohort Study
Led by Université de Sherbrooke · Updated on 2026-01-22
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating thyroid artery embolization (TAE) as a treatment option for patients with nodular goiters causing compressive symptoms who are ineligible for or refuse standard therapies like surgery or ablative treatments. This prospective interventional cohort study aims to improve data quality and follow-up to better assess the safety and effectiveness of TAE in relieving compression symptoms and reducing thyroid nodule volume. The study addresses a gap in treatment options for this specific patient population. Participants will receive thyroid artery embolization, which involves blocking the blood flow that feeds the thyroid nodule to reduce its size and relieve symptoms. There is no comparison group, as the study focuses on patients who cannot or do not want to undergo surgery. Enrollment is through convenience sampling in outpatient settings, guided by endocrinologists or otolaryngologists. Follow-ups are planned at 1 week, and 3, 6, and 12 months after the procedure. During the study, participants will undergo assessments including thyroid nodule volume measurement and evaluation of compressive symptoms at multiple post-procedure timepoints. Safety will be monitored through adverse event reports on the day of embolization and during follow-ups. Thyroid and parathyroid function tests will be performed at baseline, around 48 hours post-procedure, and at several intervals up to 12 months. Overall, the study involves careful monitoring of both effectiveness and safety over a year.
CONDITIONS
Brief Title
Thyroid Artery Embolization for the Treatment of Compressive Goiters.
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patient has compressive symptoms or significant tracheal or esophageal compression caused by a goiter
- Ineligible for surgery or ablative treatments or prefers thyroid artery embolization over other treatments
- Thyroid nodules classified as TiRADS category 1, 2, 3, or 4
- Biopsy results showing Bethesda category I or III on two biopsies, or Bethesda II on one biopsy
- Patient is at least 18 years old
You will not qualify if you...
- Presence of other medical conditions that prevent endovascular procedures
- Thyroid nodules classified as TiRADS category 5
- Biopsy results showing Bethesda categories IV, V, or VI
- Patient refuses to participate
- Uncontrolled severe hyperthyroidism
- Patient is a minor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Day of embolization
Participants undergo thyroid artery embolization to interrupt blood flow to the thyroid nodule using an embolization technique.
1 visit (in-person)
Follow-up
Duration - 12 months
Participants are monitored after treatment to assess changes in thyroid nodule volume, symptoms, and safety including thyroid and parathyroid function tests.
Visits at 48 hours, 1 week, 6 weeks, 3 months, 6 months, and 12 months after embolization
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada, J1H5H3
Actively Recruiting
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Research Team
L
Laurent Fradet, MD FRCSC
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Haipeng Xiao, Wenquan Zhuang, Shenming Wang...
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E V Galkin, B S Grakov, A V Protopopov
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Michael T McDermott
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Hyun Kyung Lim, Jeong Hyun Lee, Eun Ju Ha...
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Shi-Hui Guan, Hui Wang, Deng-Ke Teng
https://pubmed.ncbi.nlm.nih.gov/32369708Laser, radiofrequency, and ethanol ablation for the management of thyroid nodules.
Enrico Papini, Rinaldo Gugliemi, Claudio Maurizio Pacella
https://pubmed.ncbi.nlm.nih.gov/275049932015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Bryan R Haugen, Erik K Alexander, Keith C Bible...
https://pubmed.ncbi.nlm.nih.gov/26462967Solitary thyroid nodule: the risk of cancer and the extent of surgical therapy.
G A Khairy
https://pubmed.ncbi.nlm.nih.gov/15626055