Prospective Study of Thyroid Artery Embolization to Treat Compressive Goiters in Patients Unable or Unwilling to Have Surgery

What this Trial Is About

Researchers are evaluating thyroid artery embolization TAE as a treatment option for patients with nodular goiters causing compressive symptoms who are ineligible for or refuse standard therapies like surgery or ablative treatments. This prospective interventional cohort study aims to improve data quality and follow-up to better assess the safety and effectiveness of TAE in relieving compression symptoms and reducing thyroid nodule volume. The study addresses a gap in treatment options for this specific patient population. Participants will receive thyroid artery embolization, which involves blocking the blood flow that feeds the thyroid nodule to reduce its size and relieve symptoms. There is no comparison group, as the study focuses on patients who cannot or do not want to undergo surgery. Enrollment is through convenience sampling in outpatient settings, guided by endocrinologists or otolaryngologists. Follow-ups are planned at 1 week, and 3, 6, and 12 months after the procedure. During the study, participants will undergo assessments including thyroid nodule volume measurement and evaluation of compressive symptoms at multiple post-procedure timepoints. Safety will be monitored through adverse event reports on the day of embolization and during follow-ups. Thyroid and parathyroid function tests will be performed at baseline, around 48 hours post-procedure, and at several intervals up to 12 months. Overall, the study involves careful monitoring of both effectiveness and safety over a year.

Thyroid Artery Embolization for the Treatment of Compressive Goiters.