Actively Recruiting
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
Led by Seoul National University Bundang Hospital · Updated on 2026-02-02
338
Participants Needed
1
Research Sites
782 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to find out whether levothyroxine reduces complications and improves the prognosis of patients with subclinical hypothyroidism (SCH) undergoing coronary artery bypass grafting (CABG). The main questions this study aims to answer are: • Does levothyroxine reduce major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and new arrhythmias, in SCH patients undergoing CABG? Researchers will compare patients who take levothyroxine with those who do not. Participants will: * Be randomly assigned to either receive levothyroxine or not * Start the medication one day before surgery if assigned to the treatment group. * Have regular follow-up visits to check thyroid function and cardiovascular events for up to five years after surgery.
CONDITIONS
Official Title
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 to 90 years
- Patients scheduled to undergo coronary artery bypass graft (CABG) surgery
- Subclinical hypothyroidism, defined as normal free thyroxine (free T4) level and thyroid-stimulating hormone (TSH) level greater than 4 micro IU/mL within 31 days before surgery
You will not qualify if you...
- Patients who underwent repeat or emergency CABG surgery
- Use of levothyroxine within the previous 4 weeks
- Use of antithyroid drugs (propylthiouracil, methimazole, or carbimazole) within the previous 3 months
- Severe comorbid conditions with life expectancy less than 1 year, such as advanced malignancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Internal Medicine, Seoul National University Bundang Hospital
Seongnam-si, South Korea, 13620
Actively Recruiting
Research Team
M
Min Joo Kim, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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