Actively Recruiting
Ticagrelor De-escalation Strategy in AMI Patients
Led by Dong-A University · Updated on 2025-10-01
2312
Participants Needed
1
Research Sites
253 weeks
Total Duration
On this page
Sponsors
D
Dong-A University
Lead Sponsor
B
Biotronik SE & Co. KG
Collaborating Sponsor
AI-Summary
What this Trial Is About
DAPT de-escalation strategies to reduce bleeding include de-escalation of DAPT intensity (downgrading from potent P2Y12 inhibitor at conventional doses to either clopidogrel or reduced-dose prasugrel) or abbreviation of DAPT duration. The EASTYLE trial will evaluate a hybrid DAPT de-escalation strategy (reduced-dose ticagrelor, followed by aspirin early discontinuation) in AMI patients, compared with a conventional DAPT strategy.
CONDITIONS
Official Title
Ticagrelor De-escalation Strategy in AMI Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis with acute myocardial infarction
- Age 19 years or older
- Successful PCI with ultrathin bioresorbable polymer sirolimus-eluting stents (Orsiro; Biotronik AG)
- Provision of informed consent
You will not qualify if you...
- Any prior event of hemorrhagic stroke or intracranial hemorrhage
- Active bleeding or high risk of serious bleeding
- Bleeding disorders or coagulopathy (e.g., hemoglobin ≤ 10 g/dL, platelet count < 100,000/µL, recent transfusion)
- Allergy to stent metal, contrast media, or antiplatelet drugs
- Moderate to severe liver dysfunction (Child-Pugh class B or C)
- Need for oral anticoagulation therapy
- Current or potential pregnancy
- Treatment with strong CYP3A4 inhibitors
- Life expectancy less than 1 year
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
DongA University Hospital
Busan, South Korea, 602-715
Actively Recruiting
Research Team
M
Moo Hyun Kim, MD, PhD
CONTACT
Y
Young-Hoon Jeong, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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