Actively Recruiting
Time-restricted Eating in Patients With Moderate Chronic Kidney Disease and Albuminuria
Led by de Seigneux Sophie · Updated on 2026-05-11
50
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
D
de Seigneux Sophie
Lead Sponsor
U
University Hospital, Geneva
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic kidney disease (CKD) affects approximately 12 to 15% of adults worldwide, with an increasing incidence expected. Major causes include diabetic nephropathy, hypertension, and various glomerulonephritis. Proteinuria is a key factor in identifying and assessing the risk of CKD progression. The precise pathophysiology of CKD is not fully understood, but recent research highlights metabolic alterations, particularly in lipid and glucose metabolism. CKD progression is influenced by diet, as evidenced by recent studies. Interventions such as the ketogenic diet and time-restricted feeding show promising results in improving metabolism and may have beneficial effects on CKD. Our study aims to evaluate the impact of time-restricted eating (TRE) on proteinuria, the decline in glomerular filtration rate, and weight loss in patients with moderate CKD with albuminuria (KDIGO stage 2-3). This will allow us to better understand the efficacy of this dietary approach tailored to the individual habits of participants. The primary outcome measure will be albuminuria before and after the 12-week intervention. Secondary outcome measures will include the impact of fasting on blood pressure as assessed by 24-hour ambulatory monitoring, body composition evaluated by DXA and BIA, continuous glucose monitoring, and blood hormone profiles. Additionally, the feasibility and safety of TRE in this population will be assessed.
CONDITIONS
Official Title
Time-restricted Eating in Patients With Moderate Chronic Kidney Disease and Albuminuria
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult men and women
- Chronic Kidney Disease with KDIGO stage G2 and G3 defined by a Glomerular Filtration Rate between 30 and 90 mL/min/1.73m2
- Albuminuria stage A2 or A3, but without nephrotic-range proteinuria: 3 to 200 mg/mmol
- Body mass index 18-40 kg/m2
- Eating window of 12 hours (self-reported and measured during the run-in phase)
- Able to give informed consent and follow the study procedures for the entire duration
- Confident use of a smartphone compatible with the MyFoodRepo app (iOS, Android) and able to take regular pictures of food/drinks
You will not qualify if you...
- Pregnant and breastfeeding women, plans for maternity during the study
- Eating disorder(s)
- Other diets: low-carb, ketogenic diet, hypocaloric diets (eviction for food intolerances, vegan/vegetarian diet are not excluded)
- Uncontrolled blood pressure (> 160/100 mmHg)
- Diabetes with hypoglycemic drug(s)
- Oral corticosteroids
- Uncontrolled diabetes HbA1c > 8.5%
- Active cancer and/or oncologic treatment over the previous 12 months
- Major mental illness
- Consumption of > 7 standard units of alcohol per week for women and > 14 standard units of alcohol per week for men
- Shift work, such as evening shifts or night shifts planned during the study
- Travel/trip to a different time zone (≥ 2-hour time difference) planned during the study
- Recent treatment modification in the last 3 months, including but not limited to ACE blockers, SLGT2i, finerenone
- Patients with recent glomerulonephritis diagnosis on more than 2 immunosuppressive drugs
- Patients with kidney transplant in the last past year
- Enrolled in another interventional clinical trial (medication, medical device) over the previous 1 month and planned during the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital, Geneva
Geneva, Switzerland, 1211
Actively Recruiting
Research Team
D
Delal Dalga, MD, PhD
CONTACT
A
Anna Faivre, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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