Actively Recruiting
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
Led by University of Illinois at Chicago · Updated on 2025-07-09
255
Participants Needed
1
Research Sites
276 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Chicago
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Approximately 42% of American adults are obese, and this condition is strongly related to the development of colorectal cancer. Innovative lifestyle strategies to treat obesity and reduce colorectal cancer risk are critically needed. This research will demonstrate that time-restricted eating, a type of intermittent fasting, is an effective therapy to help obese individuals reduce and control their body weight and prevent the development of colorectal cancer.
CONDITIONS
Official Title
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 45 to 70 years old
- Body mass index (BMI) between 30 and 49.99 kg/m2
- Up to date with colorectal cancer screening
You will not qualify if you...
- History of renal disease, autoimmune disorders, immunodeficiency, malabsorptive disorder, significant gastrointestinal or liver disease, gastrointestinal surgery, severe ischemic heart disease, severe lung disease, severe mental health disorder, eating disorder, or bariatric surgery
- Abuse of alcohol (more than 50 grams/day), illicit drugs (except self-reported marijuana use), or use of combustible tobacco
- Have controlled type 2 diabetes or uncontrolled diabetes with hemoglobin A1c over 9.0%
- History of cancer treatment within the past 12 months, colorectal cancer, or genetic predisposition to colorectal cancer
- Body weight over 450 pounds (due to DXA scanner limits)
- Currently on a weight loss diet or in a formal weight loss program
- Not weight stable for 3 months before the study (weight change over 4 kg)
- Unable to keep a food diary for 7 consecutive days during screening
- Night shift workers
- Pregnant or trying to become pregnant
- Taking medications that impact study outcomes such as weight loss drugs
- Non-English speaking
- Taking anticoagulant or medications with endoscopic risk
- Taking antiviral or immunosuppressant medications
- Lack regular access to email and a computer, smartphone, or tablet
- Following a diet that includes fasting weekly
- Usually eat for less than 10 hours per day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
L
Lisa Tussing-Humphreys, PhD, MS, RD
CONTACT
K
Krista Varady, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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