Actively Recruiting
Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery
Led by National University Hospital, Singapore · Updated on 2024-06-13
162
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. One metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus, time to defecation, as well as postoperative abdominal distension (PMID:37373843). More broadly in gastrointestinal surgery, a meta-analysis of 21 randomised controlled trials similarly affirmed the speedier recovery of gastrointestinal function after surgery when probiotics were administered (PMID: 35231076). In spite of these advantages, the routine use of probiotics perioperatively for colorectal cancer surgery is not performed in Singapore. We therefore seek to perform a trial to investigate whether probiotic administration perioperatively may reduce post operative ileus rates.
CONDITIONS
Official Title
Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing planned colorectal cancer surgery with oncologic resection
- Between 21 and 99 years old at consent
- Willing to consider oral nutritional supplements
- Following an early recovery after surgery (ERAS) pathway
- Able to provide informed consent
You will not qualify if you...
- Known contraindications to probiotic use
- Undergoing emergency surgery
- Currently taking other probiotics
- Taken oral antibiotics within 7 days before study start
- Vulnerable patients, including pregnant women, inmates, or those unable to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
National University Hospital
Singapore, Singapore, 119074
Actively Recruiting
Research Team
D
Dedrick Chan, MBBS, DPhil
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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