Actively Recruiting
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation
Led by Capital Medical University · Updated on 2026-02-05
438
Participants Needed
40
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation after emergency endovascular therapy (EVT).
CONDITIONS
Official Title
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or over
- Diagnosed with large vessel occlusion acute ischemic stroke
- Emergency endovascular treatment performed within 24 hours of stroke onset
- Atrial fibrillation confirmed by ECG, inpatient telemetry, prolonged ECG monitoring, or medical records
- CT or MRI showing no hemorrhagic transformation or specific mild hemorrhagic infarction types (HI1 or HI2)
- Randomization within 72 hours of stroke onset
- Provided written informed consent from patient or authorized representative
You will not qualify if you...
- Atrial fibrillation caused by reversible conditions like thyrotoxicosis, pericarditis, recent surgery, or heart attack
- Contraindications to DOACs, including allergy to factor Xa inhibitors or thrombin inhibitors, need for vitamin K antagonists, severe kidney or liver problems, interacting medications, low platelet count, or bleeding disorders
- Use of DOACs or vitamin K antagonists within 48 hours before stroke with INR ≥1.7
- Pregnancy or breastfeeding, or positive pregnancy test at admission
- Major surgery or serious trauma within 1 month before stroke
- Active bleeding within 1 month before stroke
- Use or expected need for dual antiplatelet therapy
- Evidence of cerebral amyloid angiopathy or non-stroke brain conditions on imaging
- Modified Rankin scale score above 1 before stroke
- Unable to complete 90-day follow-up
- Participation in another drug clinical trial
- Any other investigator-determined reason for unsuitability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
Ma'anshan People's Hospital
Ma’anshan, Anhui, China
Actively Recruiting
2
Aviation General Hospital
Beijing, Beijing Municipality, China
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3
Beijing Shijingshan Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
4
Zhangzhou Municipal Hospital of Fujian Province
Zhangzhou, Fujian, China
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5
Heyuan People's Hospital
Heyuan, Guangdong, China
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6
Qinzhou First People's Hospital
Qinzhou, Guangxi, China
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7
Baoding Sixth Hospital
Baoding, Hebei, China
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8
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
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9
The Hongda Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
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10
Fangcheng County People's Hospital
Nanyang, Henan, China
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11
Nanyang Central Hospital
Nanyang, Henan, China
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12
Lushan County People's Hospital
Pingdingshan, Henan, China
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13
Xinyang Central Hospital
Xinyang, Henan, China
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14
Queshan County People's Hospital
Zhumadian, Henan, China
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15
Tianyou Hospital, Wuhan University of Science and Technology
Wuhan, Hubei, China
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16
The First Affiliated Hospital of Suzhou University
Suzhou, Jiangsu, China
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17
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China
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18
Yingkou Central Hospital
Yingkou, Liaoning, China
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19
Ordos Central Hospital
Ordos, Neimenggu, China
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20
Feicheng Hospital Of Shandong Yiyang Health Group
Feicheng, Shandong, China
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21
Jinan Zhangqiu District People's Hospital
Jinan, Shandong, China
Actively Recruiting
22
Laizhou City People's Hospital
Laizhou, Shandong, China
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23
Liaocheng Neurological Hospital
Liaocheng, Shandong, China
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24
Linyi People's Hospital
Linyi, Shandong, China
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25
Linshu County People's Hospital
Xiazhuang, Shandong, China
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26
Yantai Yeda Hospital
Yantai, Shandong, China
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27
Guoyao Northern Hospital (Baotou)
Baotou, Shanxi, China
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28
ShanXi Cardiovascular Hospital
Taiyuan, Shanxi, China
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29
The Second Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
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30
The People's Hospital of Yueqing
Yueqing, Zhejiang, China
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31
Xuanwu Hospital, Beijing, Beijing 100053
Beijing, China
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32
Guoluo Prefecture People's Hospital
Guoluo, China
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33
Huanghua Municipal People's Hospital
Huanghua, China
Actively Recruiting
34
First Affiliated Hospital of Henan Polytechnic University
Jiaozuo, China
Actively Recruiting
35
Qilu Hospital of Shandong University
Jinan, China
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36
Ningjin County People's Hospital
Ningjin, China
Actively Recruiting
37
Ren Shou County People's Hospital
Renshou, China
Actively Recruiting
38
Daliuta Experimental District People's Hospital of Shenmu City
Shenmu, China
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39
Xiuyan Central Hospital
Xiuyan, China
Actively Recruiting
40
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Actively Recruiting
Research Team
X
Xunming Ji
CONTACT
C
Chuanjie Wu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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