Actively Recruiting
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2
Led by Capital Medical University · Updated on 2026-02-05
240
Participants Needed
37
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation after endovascular treatment.
CONDITIONS
Official Title
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or over
- Clinical diagnosis of large vessel occlusion acute ischemic stroke
- Emergency endovascular treatment performed within 24 hours of stroke onset
- Atrial fibrillation confirmed by ECG, inpatient telemetry, prolonged ECG monitoring, or medical records
- CT or MRI showing parenchymatous hematoma type 1 or 2, intracerebral hemorrhage outside infarcted tissue, or intracranial-extracerebral hemorrhage
- Time from stroke onset to randomization between 7 days and 4 weeks
- Written informed consent from patient or legally authorized representative
You will not qualify if you...
- Atrial fibrillation caused by reversible conditions such as thyrotoxicosis, pericarditis, recent surgery, or myocardial infarction
- Contraindications to DOACs including allergy or intolerance to factor Xa inhibitors and thrombin inhibitors
- Need for vitamin K antagonist treatment due to mechanical heart valve or valvular atrial fibrillation
- Severe kidney impairment or significant liver dysfunction
- Concomitant use of medications strongly interacting with DOACs such as azole antifungals, HIV protease inhibitors, or strong CYP3A4 inducers
- Low baseline platelet count (<100 x 10^9/L)
- History of coagulopathy or systemic bleeding
- Use of DOACs within 48 hours before stroke or recent vitamin K antagonist use with INR ≥1.7 at randomization
- Pregnancy or breastfeeding, or positive pregnancy test at admission
- Major surgery or severe trauma within 1 month before stroke
- Active bleeding within 1 month before stroke
- Use or expected use of dual antiplatelet therapy during the trial
- Evidence of cerebral amyloid angiopathy
- CT or MRI showing non-stroke causes for symptoms such as mass lesions or encephalitis
- Modified Rankin scale score greater than 1 before stroke
- Inability to complete 90-day follow-up
- Participation in another drug clinical trial
- Any other investigator-determined reason making participation unsuitable
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 37 locations
1
Ma'anshan People's Hospital
Ma’anshan, Anhui, China
Actively Recruiting
2
Xuanwu Hospital
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
3
Aviation General Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
4
Beijing Shijingshan Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
5
Zhangzhou Municipal Hospital of Fujian Province
Zhangzhou, Fujian, China
Actively Recruiting
6
Heyuan People's Hospital
Heyuan, Guangdong, China
Actively Recruiting
7
Qinzhou First People's Hospital
Qinzhou, Guangxi, China
Actively Recruiting
8
Baoding Sixth Hospital
Baoding, Hebei, China
Actively Recruiting
9
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Actively Recruiting
10
The Hongda Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
Actively Recruiting
11
Fangcheng County People's Hospital
Nanyang, Henan, China
Actively Recruiting
12
Nanyang Central Hospital
Nanyang, Henan, China
Actively Recruiting
13
Lushan County People's Hospital
Pingdingshan, Henan, China
Actively Recruiting
14
Xinyang Central Hospital
Xinyang, Henan, China
Actively Recruiting
15
Queshan County People's Hospital
Zhumadian, Henan, China
Actively Recruiting
16
Tianyou Hospital, Wuhan University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
17
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China
Actively Recruiting
18
Yingkou Central Hospital
Yingkou, Liaoning, China
Actively Recruiting
19
Ordos Central Hospital,
Ordos, Neimenggu, China
Actively Recruiting
20
Feicheng Hospital Of Shandong Yiyang Health Group
Feicheng, Shandong, China
Actively Recruiting
21
Jinan Zhangqiu District People's Hospital
Jinan, Shandong, China
Actively Recruiting
22
Qilu Hospital of Shandong University
Jinan, Shandong, China
Actively Recruiting
23
Laizhou City People's Hospital,
Laizhou, Shandong, China
Actively Recruiting
24
Linyi People's Hospital
Linyi, Shandong, China
Actively Recruiting
25
Linshu County People's Hospital
Lishui, Shandong, China
Actively Recruiting
26
Yantai Yeda Hospital
Yantai, Shandong, China
Actively Recruiting
27
Guoyao Northern Hospital (Baotou)
Baotou, Shanxi, China
Actively Recruiting
28
ShanXi Cardiovascular Hospital
Taiyuan, Shanxi, China
Actively Recruiting
29
The Second Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
Actively Recruiting
30
Guoluo Prefecture People's Hospital
Guoluo, China
Actively Recruiting
31
Huanghua Municipal People's Hospital
Huanghua, China
Actively Recruiting
32
First Affiliated Hospital of Henan Polytechnic University
Jiaozuo, China
Actively Recruiting
33
Ningjin County People's Hospital
Ningjin, China
Actively Recruiting
34
Ren Shou County People's Hospital
Renshou, China
Actively Recruiting
35
Daliuta Experimental District People's Hospital of Shenmu City
Shenmu, China
Actively Recruiting
36
Xiuyan Central Hospital
Xiuyan, China
Actively Recruiting
37
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Actively Recruiting
Research Team
X
Xunming Ji
CONTACT
C
Chuanjie Wu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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