Study Comparing Immediate Versus Delayed Coronary Angiography in Adults with NSTEMI and Acute Heart Failure

What this Trial Is About

Researchers are investigating the best timing for coronary angiography CAG in patients who have non-ST-segment elevation myocardial infarction NSTEMI complicated by acute decompensated heart failure AHF. The study aims to compare immediate CAG performed within 2 hours of NSTEMI diagnosis versus delayed CAG after the patients symptoms have stabilized. This trial addresses the lack of randomized clinical data on optimal CAG timing in this high-risk group, despite current guidelines recommending early intervention. Participants will be randomly assigned to one of two groups one receiving coronary angiography within 2 hours after NSTEMI diagnosis, and the other undergoing angiography after stabilization of acute heart failure symptoms, such as improved breathing and reduced pulmonary congestion. The study is open-label and multicenter, focusing on evaluating both the efficacy and safety of immediate versus delayed CAG in these patients. During the study, researchers will monitor participants for outcomes including death from any cause, non-fatal heart attacks, and hospitalizations for heart failure over a 12-month period. Additional assessments include tracking cardiovascular events, bleeding, kidney injury, and in-hospital death rates at various time points up to 36 months. Participants clinical status will be followed closely throughout hospitalization and after discharge to evaluate the long-term effects of the timing of coronary angiography.

Timing of Coronary Angiography in NSTEMI Complicated by Acute HF