Actively Recruiting
Timing and Dose of Fluid Deresuscitation in Critically Ill Patients
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-01-21
150
Participants Needed
2
Research Sites
71 weeks
Total Duration
On this page
Sponsors
A
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead Sponsor
O
OLVG
Collaborating Sponsor
AI-Summary
What this Trial Is About
Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation. This study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.
CONDITIONS
Official Title
Timing and Dose of Fluid Deresuscitation in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admission to one of the participating ICUs;
- Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay.
You will not qualify if you...
- Age below 18 years old;
- Major cardiac shunts;
- Moderate to severe aortic regurgitation;
- Morbid Obesisty (BMI >40);
- POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease);
- PLR or modified form of PLR impossible (i.e. ECMO);
- Transfer from another ICU;
- Previous inclusion in this study;
- Patients who are moribund or facing the end of life;
- Opt out.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
OLVG
Amsterdam, Netherlands, 1091AC
Actively Recruiting
2
Amsterdam UMC
Amsterdam, Netherlands, 1105AZ
Actively Recruiting
Research Team
K
Krijna Opschoor, MD
CONTACT
S
Santje A.S. Slot, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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