Actively Recruiting
Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage
Led by Pirogov Russian National Research Medical University · Updated on 2026-03-24
200
Participants Needed
1
Research Sites
218 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this randomized clinical trial is to evaluate the safety and efficiency of different anticoagulation schemes with heparin for venous thromboembolism prevention in patients with hypertensive intracerebral hemorrhage. The main questions it aims to answer are: * What is the optimal time for the beginning of anticoagulation with heparin to efficiently prevent venous thromboembolism in patients with hypertensive intracerebral hemorrhage? Early beginning (within the first 2 days but not earlier than 12 hours after the admission of a patient) or delayed beginning (on the third day after the admission of a patient)? * Which of the two timeframes (early or delayed) for anticoagulation beginning is the most safe in terms of bleeding complications including intracerebral hemorrhage expansion? Researchers will compare the results of early and delayed start of anticoagulation using heparin in patients with hypertensive intracerebral hemorrhage to define the optimal start time for anticoagulation that provides the most favourable efficiency/safety profile. Participants will: * Undergo a computed tomography (CT) scan of the brain on hospital admission and then 12-24 hours after the hospital admission and 24 hours after the beginning of venous thromboembolism prophylaxis using heparin; * Undergo the ultrasound examination of lower extremity deep veins on hospital admission and then once every 7 days; * Receive prophylactic doses of low molecular weight heparin or unfractionated heparin either beginning within the first 2 days but not earlier than 12 hours after the hospital admission or starting on the 3rd day after the hospital admission.
CONDITIONS
Official Title
Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of hypertensive intracerebral hemorrhage
You will not qualify if you...
- Brain hemorrhage expansion detected on CT scan 12-24 hours after hospital admission before starting heparin
- Use of anticoagulants before or on the day of hospital admission
- Death within the first 2 days after hospital admission
- Blood clot detected at hospital admission
- Surgical treatment of hypertensive intracerebral hemorrhage before starting heparin
- Presence of cancer at hospital admission
AI-Screening
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Trial Site Locations
Total: 1 location
1
Moscow City Clinical Hospital named after V.M. Buyanov
Moscow, Russia, 115516
Actively Recruiting
Research Team
A
Alexander Pryamikov, MD, PhD, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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