Actively Recruiting
Tirofiban With Sequential Dual Antiplatelet Therapy in Mild Stroke
Led by Second Affiliated Hospital of Soochow University · Updated on 2025-07-31
580
Participants Needed
18
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate whether initiating intravenous tirofiban within 48 hours of onset (with a 48-hour infusion), followed by sequential DAPT, can improve the likelihood of excellent functional outcomes (modified Rankin Scale score 0-1) in mild stroke patients, compared with standard DAPT therapy based on current guidelines.
CONDITIONS
Official Title
Tirofiban With Sequential Dual Antiplatelet Therapy in Mild Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- Acute mild non-cardioembolic ischemic stroke
- NIHSS score of 5 or less
- Time from stroke onset or last known well to randomization within 48 hours
- Ability to receive the investigational drug within 48 hours of symptom onset
- Signed informed consent by patient or legal representative
You will not qualify if you...
- Received or planned intravenous thrombolysis or bridging therapy with endovascular treatment
- Intracranial hemorrhage confirmed by imaging
- Pre-stroke modified Rankin Scale score of 2 or higher
- Any confirmed cardioembolic source such as atrial fibrillation or mechanical heart valve
- History of primary intracerebral hemorrhage
- History of other intracranial hemorrhages (intraventricular, subarachnoid, epidural, or subdural)
- Untreated or inadequately treated intracranial aneurysm or vascular malformation
- Major systemic bleeding within 30 days
- Active bleeding or blood clotting problems, including low platelets or recent anticoagulant use
- Major surgery within 14 days
- Persistently high blood pressure despite treatment (systolic >180 mmHg or diastolic >110 mmHg)
- Baseline platelet count below 100 x 10^9/L
- Severe kidney dysfunction
- Allergy or contraindication to tirofiban or aspirin
- Current pregnancy or breastfeeding
- Any intracranial tumor except small asymptomatic meningiomas
- Terminal illness with life expectancy less than 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 18 locations
1
Suzhou Municipal Hospital of Anhui Province
Suzhou, Anhui, China
Actively Recruiting
2
Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Actively Recruiting
3
Taikang Xian People's Hospital
Zhoukou, Henan, China
Actively Recruiting
4
WuYuan County People's Hospital
Bayan Nur, Inner Mongolia, China
Actively Recruiting
5
Huai'an First People's Hospital
Huai'an, Jiangsu, China
Actively Recruiting
6
Jiangsu Province (Suqian) Hospital
Suqian, Jiangsu, China
Actively Recruiting
7
Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215004
Actively Recruiting
8
Affiliated Jiangsu Shengze Hospital of Nanjing Medical University
Suzhou, Jiangsu, China
Actively Recruiting
9
Changshu No.1 People's Hospital
Suzhou, Jiangsu, China
Actively Recruiting
10
First People's Hospital of Kunshan
Suzhou, Jiangsu, China
Actively Recruiting
11
Suzhou Ninth People's Hospital
Suzhou, Jiangsu, China
Actively Recruiting
12
Suzhou Xiangcheng People's Hospital
Suzhou, Jiangsu, China
Actively Recruiting
13
Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine
Suzhou, Jiangsu, China
Actively Recruiting
14
Zhangjiagang Hospital of Traditional Chinese Medicine
Suzhou, Jiangsu, China
Actively Recruiting
15
Taixing Second People's Hospital
Taizhou, Jiangsu, China
Actively Recruiting
16
Nuclear Industry 417 Hospital
Xi'an, Shaanxi, China
Actively Recruiting
17
First People's Hospital of Xianyang
Xianyang, Shaanxi, China
Actively Recruiting
18
Second Hospital of Tianjin Medical University
Tianjin, China
Actively Recruiting
Research Team
J
Jijun Shi, M.D
CONTACT
Y
Yongjun Cao, M.D, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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