Actively Recruiting
TIS for NSSI in Adolescent Depression
Led by The Second Hospital of Anhui Medical University · Updated on 2026-04-28
60
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain. This trial will compare the effectiveness of TIS to a placebo control on non-suicidal self injury (NSSI) in patients with major depressive disorder(MDD).
CONDITIONS
Official Title
TIS for NSSI in Adolescent Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the DSM-5 criteria for major depressive disorder
- Be aged 12 to 22 years with at least one guardian to monitor for 3 months
- Have a Hamilton Rating Scale for Depression (HAMD-17) total score of 18 or higher
- Have two or more non-suicidal self-injury behaviors meeting DSM-5 criteria within 2 weeks before admission
- Have had NSSI behavior on more than 5 days in the past year
- Provide informed consent from patient and guardian
You will not qualify if you...
- Abuse of psychoactive drugs or alcohol
- Severe physical disability preventing follow-up completion
- Diagnosis of other major mental illnesses like bipolar disorder, schizophrenia, mental retardation, dementia, severe cognitive impairment, or ADHD
- Presence of severe physical disease, neurological disease, or traumatic brain injury affecting brain structure or function
- Inability to read, understand, complete assessments, or cooperate with investigators
- Presence of implants such as pacemakers, metal, or magnetic objects unsuitable for TIS
- Receipt of systematic psychotherapy or transcranial magnetic stimulation within 3 months before baseline
- Other examination abnormalities deemed inappropriate by investigators
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230022
Actively Recruiting
Research Team
Y
Yanghua Tian, PhD
CONTACT
H
Hongping Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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