Clinical Study Using Patients Own Bone Marrow Stem Cells to Repair Knee Joint Cartilage Damage

What this Trial Is About

Damage to joint cartilage caused by trauma, degeneration, inflammation, or tumors often worsens over time, leading to osteoarthritis and reduced joint function. Traditional surgeries for cartilage repair are limited to small injuries and may not provide lasting results. Researchers are exploring tissue engineering using bone marrow mesenchymal stem cells BMSCs combined with three-dimensional materials to create living cartilage that can repair joint defects and restore function. This study evaluates cartilage constructed with autologous BMSCs and degradable scaffold materials to repair joint cartilage defects, particularly in the knees weight-bearing femoral condyle. The treatment involves in vitro construction of cartilage tissue using a patients own stem cells, which have good cartilage-forming ability and can be collected with minimal trauma. This approach builds on previous successful animal studies and exploratory clinical research, aiming to achieve effective cartilage repair. Participants aged 18 to 65 with specific localized cartilage defects will receive the engineered cartilage implant. Researchers will assess their knee function using KSS, Koos, Lysholm, and WOMAC scores before surgery and at 3, 6, 12, and 24 months afterward. Patients will follow a strict postoperative rehabilitation program, and safety and effectiveness will be monitored during this follow-up period, which extends up to two years after treatment.

Tissue Engineered Cartilage to Repairing Articular Cartilage Defects