Actively Recruiting
Clinical Study of Cartilage Constructed by Autologous Bone Marrow Mesenchymal Stem Cells in Repairing Articular Cartilage Defects
Led by The First Affiliated Hospital of Xinxiang Medical College · Updated on 2026-05-04
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Damage to joint cartilage caused by trauma, degeneration, inflammation, or tumors often worsens over time, leading to osteoarthritis and reduced joint function. Traditional surgeries for cartilage repair are limited to small injuries and may not provide lasting results. Researchers are exploring tissue engineering using bone marrow mesenchymal stem cells (BMSCs) combined with three-dimensional materials to create living cartilage that can repair joint defects and restore function. This study evaluates cartilage constructed with autologous BMSCs and degradable scaffold materials to repair joint cartilage defects, particularly in the knee's weight-bearing femoral condyle. The treatment involves in vitro construction of cartilage tissue using a patient's own stem cells, which have good cartilage-forming ability and can be collected with minimal trauma. This approach builds on previous successful animal studies and exploratory clinical research, aiming to achieve effective cartilage repair. Participants aged 18 to 65 with specific localized cartilage defects will receive the engineered cartilage implant. Researchers will assess their knee function using KSS, Koos, Lysholm, and WOMAC scores before surgery and at 3, 6, 12, and 24 months afterward. Patients will follow a strict postoperative rehabilitation program, and safety and effectiveness will be monitored during this follow-up period, which extends up to two years after treatment.
CONDITIONS
Brief Title
Tissue Engineered Cartilage to Repairing Articular Cartilage Defects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years, any gender
- Mature epiphyseal growth confirmed by imaging
- Defects or localized joint cartilage injuries caused by trauma or other reasons
- Injured area is the distal weight-bearing surface of the femoral condyle of the knee joint, with no more than 4 lesions
- No injury to the cruciate ligaments
- Voluntarily signed informed consent and willingness to follow strict postoperative rehabilitation
You will not qualify if you...
- Body mass index greater than 35
- Lower limb alignment valgus over 10 degrees or varus over 5 degrees
- Multiple ligament injuries
- Heavy smoking, drug abuse, or excessive alcohol consumption
- Open knee joint surgery within past 6 months
- Severe joint stiffness or fibrosis
- Allergic history to collagen or allergic constitution
- Mental abnormalities
- Unable or unwilling to undergo rehabilitation training
- Primary cardiovascular, lung, endocrine, metabolic diseases, tumors, or AIDS
- Pregnant, lactating, or planning pregnancy during trial
- Other acute or chronic diseases making surgery inappropriate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants receive a cartilage construct made from their own bone marrow mesenchymal stem cells to repair joint cartilage defects.
1 visit (in-person)
Duration - Up to 24 months after surgery
Participants are monitored through scheduled visits to assess recovery and the effectiveness of the cartilage repair.
Visits at 3, 6, 12, and 24 months post-operation
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Xinxiang Medical College
Xinxiang, Henan, China, 453000
Actively Recruiting
Research Team
W
Wenjie Ren
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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