Anaplastic Lymphoma Kinase Gene Rearrangement in Children and Young Adults With Mesothelioma.
Idrees Mian, Zied Abdullaev, Betsy Morrow...
https://pubmed.ncbi.nlm.nih.gov/31783178Actively Recruiting
Age: 2Years - 100Years
All Genders
ID01950572
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma and Other Mesothelin Expressing Cancers
Led by National Cancer Institute (NCI) · Updated on 2026-06-05
1000
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Malignant mesothelioma is a rare cancer that originates from the mesothelial cells lining the pleura, peritoneum, pericardium, or tunica vaginalis. This research is focused on studying mesothelioma and other cancers that express mesothelin, including thymic carcinoma, pancreatic, biliary adenocarcinomas, lung, gastric, and ovarian cancers. The study aims to collect tissue samples to better understand these diseases and their progression. Participants include those aged 2 years or older with malignant mesothelioma and individuals aged 18 years or older with other mesothelin-expressing cancers. Up to 1,000 participants will be enrolled. During the study, blood, urine, tumor tissue, and abnormal body fluids will be collected for tissue banking. These samples may be used for genetic, genomic, cell culture, and immunologic studies. Participants will be followed over time to observe the course of their disease and any treatments they receive. The study includes ongoing collection of biological samples for research purposes. The primary outcome measure is continual sample acquisition, helping researchers study mesothelioma and related cancers more thoroughly. This observational study does not involve treatment but focuses on natural disease history and sample collection.
CONDITIONS
Brief Title
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Who Can Participate
Age: 2Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- All participants 2 years of age or older with malignant mesothelioma
- All participants 18 years of age or older with thymic carcinoma, pancreatic or biliary adenocarcinoma, lung, gastric, ovarian cancers, or other solid tumors known to express mesothelin
- Confirmed pathological diagnosis of eligible cancer
- Ability and willingness to provide informed consent or have a parent/guardian provide consent if under 18
You will not qualify if you...
- Active symptomatic major organ disorders increasing biopsy risk, such as ischemic heart disease, recent heart attack, active heart failure, or pulmonary dysfunction
- Pregnant women
- Active medical or psychological illnesses that may increase risk or inability to provide informed consent, at the investigator's discretion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Ongoing
Participants provide samples of blood, urine, tumor, and abnormal body fluids for tissue banking and research purposes.
Visits as needed for sample collection
Long-term Monitoring
Duration - Up to 10 years
Participants are followed over time to determine the course of disease and to record any treatment received for their cancer.
Periodic visits depending on disease course and treatment
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
M
Maria Gracia L Agra, R.N.
R
Raffit Hassan, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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